ENSG00000069869


Homo sapiens

Features
Gene ID: ENSG00000069869
  
Biological name :NEDD4
  
Synonyms : NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.3
Gene start: 55826922
Gene end: 55993746
  
Corresponding Affymetrix probe sets: 213012_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426051
Ensembl peptide - ENSP00000424471
Ensembl peptide - ENSP00000424827
Ensembl peptide - ENSP00000345530
Ensembl peptide - ENSP00000410613
Ensembl peptide - ENSP00000421047
Ensembl peptide - ENSP00000422455
Ensembl peptide - ENSP00000422705
NCBI entrez gene - 4734     See in Manteia.
OMIM - 602278
RefSeq - XM_011521627
RefSeq - NM_001284338
RefSeq - NM_001284339
RefSeq - NM_001284340
RefSeq - NM_001329212
RefSeq - NM_006154
RefSeq - NM_198400
RefSeq - XM_011521624
RefSeq - XM_011521625
RefSeq - XM_011521626
RefSeq Peptide - NP_001271267
RefSeq Peptide - NP_001271268
RefSeq Peptide - NP_001271269
RefSeq Peptide - NP_001316141
RefSeq Peptide - NP_006145
RefSeq Peptide - NP_940682
swissprot - H0Y8H4
swissprot - H0Y8X6
swissprot - H0Y9L1
swissprot - H0YA37
swissprot - P46934
Ensembl - ENSG00000069869
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd4aENSDARG00000099843Danio rerio
 NEDD4ENSGALG00000004347Gallus gallus
 Nedd4ENSMUSG00000032216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG0000004975943
HECW1 / Q76N89 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1ENSG0000000274624
WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1ENSG0000012312424
HECW2 / Q9P2P5 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2ENSG0000013841124
ITCH / Q96J02 / itchy E3 ubiquitin protein ligaseENSG0000007874724
WWP2 / O00308 / WW domain containing E3 ubiquitin protein ligase 2ENSG0000019837323
Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2ENSG0000010885422
Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1ENSG0000019874221
HACE1 / Q8IYU2 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1ENSG0000008538216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006622 protein targeting to lysosome IDA
 biological_processGO:0007041 lysosomal transport IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010766 negative regulation of sodium ion transport IDA
 biological_processGO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019089 transmission of virus IMP
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0031175 neuron projection development IEP
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032801 receptor catabolic process IDA
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IDA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IDA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0044111 development involved in symbiotic interaction IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0046824 positive regulation of nucleocytoplasmic transport IDA
 biological_processGO:0048814 regulation of dendrite morphogenesis ISS
 biological_processGO:0050847 progesterone receptor signaling pathway IDA
 biological_processGO:0051592 response to calcium ion TAS
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IDA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0000151 ubiquitin ligase complex ISS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity IDA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031698 beta-2 adrenergic receptor binding IDA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0050815 phosphoserine residue binding ISS
 molecular_functionGO:0050816 phosphothreonine residue binding ISS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0070063 RNA polymerase binding IPI
 molecular_functionGO:0070064 proline-rich region binding IMP


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000187608 ISG15 / P05161 / ISG15 ubiquitin-like modifier  / complex / reaction






 

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