ENSMUSG00000032216


Mus musculus

Features
Gene ID: ENSMUSG00000032216
  
Biological name :Nedd4
  
Synonyms : Nedd4 / neural precursor cell expressed, developmentally down-regulated 4 / P46935
  
Possible biological names infered from orthology : neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 72662346
Gene end: 72749852
  
Corresponding Affymetrix probe sets: 10586933 (MoGene1.0st)   1421955_a_at (Mouse Genome 430 2.0 Array)   1450431_a_at (Mouse Genome 430 2.0 Array)   1451109_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138852
Ensembl peptide - ENSMUSP00000139190
Ensembl peptide - ENSMUSP00000139297
Ensembl peptide - ENSMUSP00000034740
Ensembl peptide - ENSMUSP00000138983
NCBI entrez gene - 17999     See in Manteia.
MGI - MGI:97297
RefSeq - XM_011242672
RefSeq - NM_010890
RefSeq Peptide - NP_035020
swissprot - P46935
swissprot - Q3V335
swissprot - V9GWV8
swissprot - V9GXK3
swissprot - V9GXS6
swissprot - B2RSC8
Ensembl - ENSMUSG00000032216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd4aENSDARG00000099843Danio rerio
 NEDD4ENSGALG00000004347Gallus gallus
 NEDD4ENSG00000069869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*ENSMUSG0000002458962
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759834
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105834
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000004280733
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSMUSG0000002130133
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*ENSMUSG0000001836332
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*ENSMUSG0000003193032
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878029
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0006622 protein targeting to lysosome IEA
 biological_processGO:0007041 lysosomal transport IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0010766 negative regulation of sodium ion transport IDA
 biological_processGO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0019089 transmission of virus IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
 biological_processGO:0044111 development involved in symbiotic interaction IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0046824 positive regulation of nucleocytoplasmic transport IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0050807 regulation of synapse organization IMP
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IPI
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity IDA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031698 beta-2 adrenergic receptor binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IDA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0050815 phosphoserine residue binding IDA
 molecular_functionGO:0050816 phosphothreonine residue binding IDA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0070063 RNA polymerase binding IEA
 molecular_functionGO:0070064 proline-rich region binding IPI


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Nedd4tm2Bros/Nedd4tm2Bros
Genetic Background: involves: C57BL/6N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Nedd4tm3.1Bros/Nedd4tm3.1Bros,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Nedd4tm3.1Bros/Nedd4tm3.1Bros,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * SJL

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss * C57BL/6 * CD-1 * DBA/2

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pax1un/Pax1un
Genetic Background: Not Specified

Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nedd4tm2Bros/Nedd4tm2Bros
Genetic Background: involves: C57BL/6N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Krt25M2Btlr/Krt25+
Genetic Background: C57BL/6J-Krt25M2Btlr

Allelic Composition: Nedd4Gt(XB786)Byg/Nedd4Gt(XB786)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nedd4tm2Bros/Nedd4tm2Bros
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction






 

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