ENSMUSG00000062209


Mus musculus

Features
Gene ID: ENSMUSG00000062209
  
Biological name :Erbb4
  
Synonyms : Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 4 / Q15303
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 68032186
Gene end: 69108059
  
Corresponding Affymetrix probe sets: 10355278 (MoGene1.0st)   1427783_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112713
Ensembl peptide - ENSMUSP00000114123
Ensembl peptide - ENSMUSP00000115373
NCBI entrez gene - 13869     See in Manteia.
MGI - MGI:104771
RefSeq - XM_006495695
RefSeq - NM_010154
RefSeq - XM_006495692
RefSeq - XM_006495693
RefSeq - XM_006495694
RefSeq Peptide - NP_034284
swissprot - Q61527
swissprot - B2KGF7
Ensembl - ENSMUSG00000062209
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egfraENSDARG00000013847Danio rerio
 LO018309.1ENSDARG00000056909Danio rerio
 ERBB4ENSGALG00000003126Gallus gallus
 ERBB4ENSG00000178568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012250
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816648
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231246
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945616
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260715
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279113
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145713
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611712
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:0021889 olfactory bulb interneuron differentiation IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060644 mammary gland epithelial cell differentiation IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IGI
 biological_processGO:2001223 negative regulation of neuron migration IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0038132 neuregulin binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
Downregulation of ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0002271 abnormal alveolar duct morphology "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Fej/Erbb4tm1Fej,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003458 Ncstn / P57716 / Nicastrin / Q92542*  / reaction
 ENSMUSG00000004637 Wwox / Q91WL8 / WW domain-containing oxidoreductase / Q9NZC7*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000015750 Aph1a / Q8BVF7 / Gamma-secretase subunit APH-1A / Q96BI3* / aph-1 homolog A, gamma-secretase subunit*  / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000010609 Psen2 / presenilin 2 / P49810*  / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000032375 Aph1b / Q8C7N7 / Gamma-secretase subunit APH-1B / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000019969 Psen1 / P49769 / presenilin 1 / P49768*  / reaction
 ENSMUSG00000036835 Psenen / Q9CQR7 / Gamma-secretase subunit PEN-2 / Q9NZ42* / AD000671.1* / presenilin enhancer gamma-secretase subunit*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000053040 Aph1c / Q9DCZ9 / Putative gamma-secretase subunit APH-1C / APH1B* / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / reaction / complex
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction / complex
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / reaction / complex
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000032216 Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex
 ENSMUSG00000027598 Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction






 

1 s.

 
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