ENSMUSG00000058704


Mus musculus

Features
Gene ID: ENSMUSG00000058704
  
Biological name :Memo1
  
Synonyms : Memo1 / Protein MEMO1 / Q91VH6
  
Possible biological names infered from orthology : mediator of cell motility 1 / Q9Y316
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E2
Gene start: 74200706
Gene end: 74294883
  
Corresponding Affymetrix probe sets: 10452860 (MoGene1.0st)   1420339_at (Mouse Genome 430 2.0 Array)   1449821_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077553
NCBI entrez gene - 76890     See in Manteia.
MGI - MGI:1924140
RefSeq - XM_011246713
RefSeq - NM_133771
RefSeq - XM_006525109
RefSeq - XM_011246712
RefSeq Peptide - NP_598532
swissprot - Q91VH6
Ensembl - ENSMUSG00000058704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 memo1ENSDARG00000010823Danio rerio
 MEMO1ENSGALG00000010624Gallus gallus
 MEMO1ENSG00000162959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002737  MEMO1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032886 regulation of microtubule-based process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0042277 peptide binding ISO


Pathways (from Reactome)
Pathway description
ERBB2 Regulates Cell Motility


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0000653 abnormal sex gland morphology "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1+
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0012337 increased vitamin D level "greater level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex






 

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