ENSMUSG00000024486


Mus musculus

Features
Gene ID: ENSMUSG00000024486
  
Biological name :Hbegf
  
Synonyms : Hbegf / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186
  
Possible biological names infered from orthology : heparin binding EGF like growth factor / Q99075
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 36504929
Gene end: 36515805
  
Corresponding Affymetrix probe sets: 10458340 (MoGene1.0st)   1418349_at (Mouse Genome 430 2.0 Array)   1418350_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025363
NCBI entrez gene - 15200     See in Manteia.
MGI - MGI:96070
RefSeq - NM_010415
RefSeq Peptide - NP_034545
swissprot - Q06186
swissprot - Q5FW64
Ensembl - ENSMUSG00000024486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbegfaENSDARG00000075121Danio rerio
 hbegfbENSDARG00000031246Danio rerio
 HBEGFENSGALG00000000949Gallus gallus
 HBEGFENSG00000113070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcub / P31955 / amphiregulin / AREG* / P15514*ENSMUSG0000002937822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis NAS
 biological_processGO:0001832 blastocyst growth TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051545 negative regulation of elastin biosynthetic process IEA
 biological_processGO:0051549 positive regulation of keratinocyte migration IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hbegftm4Mek/Hbegftm4Mek
Genetic Background: B6.Cg-Hbegftm4Mek

Allelic Composition: Hbegftm4Mek/Hbegf+
Genetic Background: B6.Cg-Hbegftm4Mek

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: B6.Cg-Hbegftm1.1Mek

Allelic Composition: Hbegftm1.1Mek/Hbegf+
Genetic Background: B6.Cg-Hbegftm1.1Mek

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hbegftm1.1Mek/Hbegf+
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

Allelic Composition: Hbegftm4Mek/Hbegftm4Mek
Genetic Background: B6.Cg-Hbegftm4Mek

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: B6.Cg-Hbegftm1.1Mek

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004063 dilated left atrium "an expansion in the volume of the left upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hbegftm4Mek/Hbegftm4Mek
Genetic Background: B6.Cg-Hbegftm4Mek

Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: B6.Cg-Hbegftm1.1Mek

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hbegftm1.1Mek/Hbegftm1.1Mek
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000036273 Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000029816 Gpnmb / Q99P91 / Transmembrane glycoprotein NMB / Q14956* / glycoprotein nmb*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction






 

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