ENSMUSG00000029378


Mus musculus

Features
Gene ID: ENSMUSG00000029378
  
Biological name :Mcub
  
Synonyms : amphiregulin / Mcub / P31955
  
Possible biological names infered from orthology : AREG / P15514
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 91139599
Gene end: 91148432
  
Corresponding Affymetrix probe sets: 10523182 (MoGene1.0st)   1421134_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031325
NCBI entrez gene - 11839     See in Manteia.
MGI - MGI:88068
RefSeq - NM_009704
RefSeq Peptide - NP_033834
swissprot - P31955
swissprot - Q4FJT2
Ensembl - ENSMUSG00000029378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aregENSDARG00000076853Danio rerio
 AREGENSGALG00000010866Gallus gallus
 AREGENSG00000109321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*ENSMUSG0000002448618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032355 response to estradiol IDA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060744 mammary gland branching involved in thelarche IMP
 biological_processGO:0060749 mammary gland alveolus development IGI
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfap2tm1a(KOMP)Wtsi/Mfap2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0002580 duodenal lesions "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfap2tm1a(KOMP)Wtsi/Mfap2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0011237 decreased blood oxygen capacity "a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]
Show

Allelic Composition: Mfap2tm1a(KOMP)Wtsi/Mfap2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015759 1 / Cnih1 / O35372 / O95406* / cornichon family AMPA receptor auxiliary protein 1*  / complex / reaction






 

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