ENSG00000109321


Homo sapiens

Features
Gene ID: ENSG00000109321
  
Biological name :AREG
  
Synonyms : amphiregulin / AREG / P15514
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 74445134
Gene end: 74455009
  
Corresponding Affymetrix probe sets: 205239_at (Human Genome U133 Plus 2.0 Array)   215564_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379097
Ensembl peptide - ENSP00000421414
NCBI entrez gene - 374     See in Manteia.
OMIM - 104640
RefSeq - NM_001657
RefSeq Peptide - NP_001648
swissprot - D6RFX5
swissprot - P15514
Ensembl - ENSG00000109321
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aregENSDARG00000076853Danio rerio
 AREGENSGALG00000010866Gallus gallus
 McubENSMUSG00000029378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HBEGF / Q99075 / heparin binding EGF like growth factorENSG0000011307023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IMP
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100528 CNIH1 / O95406 / cornichon family AMPA receptor auxiliary protein 1  / complex / reaction






 

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