374


Homo sapiens (NCBI)
cellresponsemembranereceptorsignalingproliferationregulationmammaryglandgolgigrowthfactoractivityinvolvedertransportepidermalpathwaydevelopmentvesicleductendoplasmicbindingvesicle-mediatedg-proteincoupledcell-cellglialneuronprojection

Features
Gene ID: 374
  
Biological name :
  
Synonyms : amphiregulin / AR|AREGB|CRDGF|SDGF / AREG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 205239_at (Human Genome U133 Plus 2.0 Array)   215564_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4502199
RefSeq - NC_000004.12
RefSeq - NP_001648.1
RefSeq - NM_001657.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000109321 to get all the annotations available for this gene.


Gene Ontology (GO)
establishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestablishment of localizationcellular localizationcell communicationcellular response to stimulusregulation of molecular functionanatomical structure developmentcellular developmental processcellular component organizationresponse to endogenous stimulusresponse to chemicalresponse to stressossificationcellular component biogenesisnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthepithelial cell proliferationestabliestablishment of localizationcellulacellular localizationcell cocell communicationcellulacellular response to stimulusregulatregulation of molecular functionanatomianatomical structure developmentcellulacellular developmental processcellulacellular component organizationresponsresponse to endogenous stimulusresponsresponse to chemicalresponsresponse to stressossificossificationcellulacellular component biogenesisnitrogenitrogen compound metabolic processcellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processdevelopdevelopmental growthepithelepithelial cell proliferation
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
cellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellmembraneorganelleextracellular regioncellcellmembranemembraneorganelleorganelleextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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