Manteia

ENSG00000113070

Homo sapiens

Features

Gene ID:	ENSG00000113070

Biological name :	HBEGF

Synonyms :	HBEGF / heparin binding EGF like growth factor / Q99075

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	5
Strand:	-1
Band:	q31.3
Gene start:	140332843
Gene end:	140346631

Corresponding Affymetrix probe sets:	203821_at (Human Genome U133 Plus 2.0 Array) 222076_at (Human Genome U133 Plus 2.0 Array) 244857_at (Human Genome U133 Plus 2.0 Array) 38037_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000230990 NCBI entrez gene - 1839 See in Manteia. OMIM - 126150 RefSeq - NM_001945 RefSeq Peptide - NP_001936 swissprot - Q99075 Ensembl - ENSG00000113070

Related genetic diseases (OMIM):	126150 - {Diphtheria, susceptibility to}

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hbegfa	ENSDARG00000075121	Danio rerio
hbegfb	ENSDARG00000031246	Danio rerio
HBEGF	ENSGALG00000000949	Gallus gallus
Hbegf	ENSMUSG00000024486	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
AREG / P15514 / amphiregulin	ENSG00000109321	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000742	EGF-like domain
IPR013032	EGF-like, conserved site
IPR015497	Epidermal growth factor receptor ligand

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	IEA
biological_process	GO:0007517	muscle organ development	TAS
biological_process	GO:0008016	regulation of heart contraction	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0016477	cell migration	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030307	positive regulation of cell growth	IEA
biological_process	GO:0030335	positive regulation of cell migration	IMP
biological_process	GO:0035313	wound healing, spreading of epidermal cells	IEA
biological_process	GO:0038128	ERBB2 signaling pathway	TAS
biological_process	GO:0046854	phosphatidylinositol phosphorylation	IEA
biological_process	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0051545	negative regulation of elastin biosynthetic process	IEA
biological_process	GO:0051549	positive regulation of keratinocyte migration	IEA
biological_process	GO:0051897	positive regulation of protein kinase B signaling	TAS
biological_process	GO:0060326	cell chemotaxis	IMP
biological_process	GO:0065009	regulation of molecular function	IEA
biological_process	GO:0090303	positive regulation of wound healing	IMP
biological_process	GO:1901185	negative regulation of ERBB signaling pathway	TAS
biological_process	GO:2000145	regulation of cell motility	TAS
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005615	extracellular space	ISS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0009986	cell surface	NAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030666	endocytic vesicle membrane	TAS
cellular_component	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005154	epidermal growth factor receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	IEA
molecular_function	GO:0008201	heparin binding	IMP
molecular_function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS

Pathways (from Reactome)

Pathway description

Signaling by ERBB2

Signaling by ERBB4

SHC1 events in ERBB2 signaling

PI3K events in ERBB4 signaling

SHC1 events in ERBB4 signaling

Nuclear signaling by ERBB4

PIP3 activates AKT signaling

GRB2 events in ERBB2 signaling

PI3K events in ERBB2 signaling

EGFR Transactivation by Gastrin

Constitutive Signaling by Aberrant PI3K in Cancer

Uptake and function of diphtheria toxin

RAF/MAP kinase cascade

ERBB2 Regulates Cell Motility

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

ERBB2 Activates PTK6 Signaling

PTK6 promotes HIF1A stabilization

Downregulation of ERBB2 signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000010278	CD9 / P21926 / CD9 molecule	/ complex / reaction
ENSG00000080824	P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1	/ reaction
ENSG00000105401	CDC37 / Q16543 / cell division cycle 37	/ reaction
ENSG00000146648	EGFR / P00533 / epidermal growth factor receptor	/ reaction / complex
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ reaction / complex
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ complex / reaction
ENSG00000162959	MEMO1 / Q9Y316 / mediator of cell motility 1	/ reaction / complex
ENSG00000158458	NRG2 / O14511 / neuregulin 2	/ complex / reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000131504	DIAPH1 / O60610 / diaphanous related formin 1	/ reaction / complex
ENSG00000174808	BTC / P35070 / betacellulin	/ complex / reaction
ENSG00000157168	NRG1 / Q02297 / neuregulin 1	/ complex / reaction
ENSG00000138798	EGF / P01133 / epidermal growth factor	/ reaction / complex
ENSG00000188906	LRRK2 / Q5S007 / leucine rich repeat kinase 2	/ reaction / complex
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction
ENSG00000067560	RHOA / P61586 / ras homolog family member A	/ reaction / complex
ENSG00000136235	GPNMB / Q14956 / glycoprotein nmb	/ reaction / complex
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ reaction
ENSG00000178568	ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	/ reaction / complex
ENSG00000113070	HBEGF / Q99075 / heparin binding EGF like growth factor	/ complex / reaction
ENSG00000065361	ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3	/ reaction / complex
ENSG00000007264	MATK / P42679 / megakaryocyte-associated tyrosine kinase	/ reaction / complex
ENSG00000101213	PTK6 / Q13882 / protein tyrosine kinase 6	/ complex / reaction
ENSG00000100644	HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit	/ reaction
ENSG00000124882	EREG / O14944 / epiregulin	/ complex / reaction
ENSG00000127947	PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12	/ reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ reaction / complex
ENSG00000112851	ERBIN / Q96RT1 / erbb2 interacting protein	/ reaction
ENSG00000151694	ADAM17 / P78536 / ADAM metallopeptidase domain 17	/ reaction
ENSG00000149968	MMP3 / P08254 / matrix metallopeptidase 3	/ reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ reaction / complex
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ reaction
ENSG00000169752	NRG4 / Q8WWG1 / neuregulin 4	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr