ENSG00000136235


Homo sapiens

Features
Gene ID: ENSG00000136235
  
Biological name :GPNMB
  
Synonyms : glycoprotein nmb / GPNMB / Q14956
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p15.3
Gene start: 23235967
Gene end: 23275108
  
Corresponding Affymetrix probe sets: 1554018_at (Human Genome U133 Plus 2.0 Array)   201141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386476
Ensembl peptide - ENSP00000258733
Ensembl peptide - ENSP00000371420
NCBI entrez gene - 10457     See in Manteia.
OMIM - 604368
RefSeq - XM_017011678
RefSeq - NM_001005340
RefSeq - NM_002510
RefSeq - XM_005249578
RefSeq - XM_017011676
RefSeq - XM_017011677
RefSeq Peptide - NP_001005340
RefSeq Peptide - NP_002501
swissprot - Q96F58
swissprot - A0A024RA55
swissprot - Q14956
Ensembl - ENSG00000136235
  
Related genetic diseases (OMIM): 617920 - Amyloidosis, primary localized cutaneous, 3, 617920
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpnmbENSDARG00000062688Danio rerio
 GPNMBENSGALG00000010949Gallus gallus
 GpnmbENSMUSG00000029816Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PMEL / P40967 / premelanosome proteinENSG0000018566429


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR013783  Immunoglobulin-like fold
 IPR022409  PKD/Chitinase domain
 IPR035986  PKD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001818 negative regulation of cytokine production IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034103 regulation of tissue remodeling IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0045765 regulation of angiogenesis NAS
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0050918 positive chemotaxis NAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IC
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0042056 chemoattractant activity NAS
 molecular_functionGO:0045545 syndecan binding IPI
 molecular_functionGO:0048018 receptor ligand activity IMP


Pathways (from Reactome)
Pathway description
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction / complex
 ENSG00000188906 LRRK2 / Q5S007 / leucine rich repeat kinase 2  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex






 

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