ENSGALG00000010949


Gallus gallus

Features
Gene ID: ENSGALG00000010949
  
Biological name :GPNMB
  
Synonyms : glycoprotein nmb / GPNMB
  
Possible biological names infered from orthology : Q14956 / Q99P91 / Transmembrane glycoprotein NMB
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 31184795
Gene end: 31200167
  
Corresponding Affymetrix probe sets: GgaAffx.6931.1.S1_at (Chicken Array)   GgaAffx.6931.2.S1_at (Chicken Array)   GgaAffx.6931.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017800
NCBI entrez gene - 428431     See in Manteia.
RefSeq - XM_425991
swissprot - F1NPS6
Ensembl - ENSGALG00000010949
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpnmbENSDARG00000062688Danio rerio
 GPNMBENSG00000136235Homo sapiens
 GpnmbENSMUSG00000029816Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PMEL / melanocyte protein PMEL precursor / P40967* / premelanosome protein*ENSGALG0000003535030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR022409  PKD/Chitinase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034103 regulation of tissue remodeling IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0045545 syndecan binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000007161 LRRK2 / leucine-rich repeat serine/threonine-protein kinase 2 / Q5S006* / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction






 

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