ENSGALG00000007161


Gallus gallus

Features
Gene ID: ENSGALG00000007161
  
Biological name :LRRK2
  
Synonyms : leucine-rich repeat serine/threonine-protein kinase 2 / LRRK2
  
Possible biological names infered from orthology : leucine rich repeat kinase 2 / Q5S006 / Q5S007
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 15008474
Gene end: 15072568
  
Corresponding Affymetrix probe sets: GgaAffx.4483.1.S1_at (Chicken Array)   GgaAffx.4484.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011585
Ensembl peptide - ENSGALP00000052474
NCBI entrez gene - 427844     See in Manteia.
RefSeq - NM_001287193
RefSeq - XM_003640340
RefSeq Peptide - NP_001274122
swissprot - E1C5R5
swissprot - A0A1D5PI42
Ensembl - ENSGALG00000007161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrk2ENSDARG00000006169Danio rerio
 LRRK2ENSG00000188906Homo sapiens
 Lrrk2ENSMUSG00000036273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRK1 / leucine rich repeat kinase 1 / Q38SD2* / Q3UHC2* / Leucine-rich repeat serine/threonine-protein kinase 1 *ENSGALG0000000714113
PRKD3 / protein kinase D3 / O94806* / Q8K1Y2*ENSGALG000000106127
PRKD1 / protein kinase D1 / Q15139* / Q62101*ENSGALG000000099007


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005225  Small GTP-binding protein domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017441  Protein kinase, ATP binding site
 IPR017986  WD40-repeat-containing domain
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR025875  Leucine rich repeat 4
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032171  C-terminal of Roc (COR) domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IBA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010738 regulation of protein kinase A signaling IEA
 biological_processGO:0010955 negative regulation of protein processing IEA
 biological_processGO:0014041 regulation of neuron maturation IEA
 biological_processGO:0016242 negative regulation of macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IBA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035564 regulation of kidney size IEA
 biological_processGO:0035640 exploration behavior IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035751 regulation of lysosomal lumen pH IEA
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0046039 GTP metabolic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051646 mitochondrion localization IEA
 biological_processGO:0051900 regulation of mitochondrial depolarization IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IBA
 biological_processGO:0070997 neuron death IEA
 biological_processGO:0071287 cellular response to manganese ion IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901727 positive regulation of histone deacetylase activity IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902499 positive regulation of protein autoubiquitination IEA
 biological_processGO:1902692 regulation of neuroblast proliferation IEA
 biological_processGO:1902803 regulation of synaptic vesicle transport IBA
 biological_processGO:1902902 negative regulation of autophagosome assembly IBA
 biological_processGO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA
 biological_processGO:1903215 negative regulation of protein targeting to mitochondrion IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1904887 Wnt signalosome assembly IEA
 biological_processGO:1905279 regulation of retrograde transport, endosome to Golgi IBA
 biological_processGO:1905289 regulation of CAMKK-AMPK signaling cascade IEA
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 cellular_componentGO:0032473 cytoplasmic side of mitochondrial outer membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044753 amphisome IEA
 cellular_componentGO:0044754 autolysosome IEA
 cellular_componentGO:0045121 membrane raft IBA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097487 multivesicular body, internal vesicle IEA
 cellular_componentGO:0099400 caveola neck IEA
 cellular_componentGO:1990909 Wnt signalosome IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IBA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0034211 GTP-dependent protein kinase activity IEA
 molecular_functionGO:0036479 peroxidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051018 protein kinase A binding IEA
 molecular_functionGO:1904713 beta-catenin destruction complex binding IEA


Pathways (from Reactome)
Pathway description
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex
 ENSGALG00000010949 GPNMB / glycoprotein nmb / Q14956* / Q99P91* / Transmembrane glycoprotein NMB *  / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex






 

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