ENSGALG00000000949


Gallus gallus

Features
Gene ID: ENSGALG00000000949
  
Biological name :HBEGF
  
Synonyms : HBEGF / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q9W7C5
  
Possible biological names infered from orthology : heparin binding EGF like growth factor / Q06186 / Q99075
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 1515672
Gene end: 1521782
  
Corresponding Affymetrix probe sets: Gga.389.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001399
NCBI entrez gene - 395654     See in Manteia.
RefSeq - NM_204849
RefSeq Peptide - NP_990180
swissprot - Q9W7C5
Ensembl - ENSGALG00000000949
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbegfaENSDARG00000075121Danio rerio
 hbegfbENSDARG00000031246Danio rerio
 HBEGFENSG00000113070Homo sapiens
 HbegfENSMUSG00000024486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AREG / amphiregulin / Mcub* / P15514* / P31955*ENSGALG0000001086622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021545 cranial nerve development IMP
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051549 positive regulation of keratinocyte migration IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000007161 LRRK2 / leucine-rich repeat serine/threonine-protein kinase 2 / Q5S006* / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction / complex
 ENSGALG00000010949 GPNMB / glycoprotein nmb / Q14956* / Q99P91* / Transmembrane glycoprotein NMB *  / reaction / complex
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction / complex
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / reaction / complex
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction / complex
 ENSGALG00000000736 MATK / megakaryocyte-associated tyrosine kinase / P42679*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000010624 MEMO1 / mediator of cell motility 1 / Q91VH6* / Q9Y316* / Protein MEMO1 *  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction






 

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