ENSGALG00000015422


Gallus gallus

Features
Gene ID: ENSGALG00000015422
  
Biological name :NRG1
  
Synonyms : NRG1 / pro-neuregulin-1, membrane-bound isoform
  
Possible biological names infered from orthology : neuregulin 1 / Q02297
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 53958209
Gene end: 54246724
  
Corresponding Affymetrix probe sets: Gga.135.2.S1_at (Chicken Array)   Gga.135.2.S1_a_at (Chicken Array)   Gga.135.3.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036986
Ensembl peptide - ENSGALP00000064460
Ensembl peptide - ENSGALP00000063922
Ensembl peptide - ENSGALP00000024830
NCBI entrez gene - 373906     See in Manteia.
RefSeq - XM_015280407
RefSeq - XM_015280401
RefSeq - XM_015280403
RefSeq - XM_015280404
RefSeq - XM_015280405
RefSeq - XM_015280406
RefSeq - NM_204117
RefSeq - XM_015280396
RefSeq - XM_015280397
RefSeq - XM_015280398
RefSeq - XM_015280399
RefSeq Peptide - NP_989448
swissprot - A0A1L1S029
swissprot - A0A1L1RYK9
swissprot - F1NUM4
swissprot - A0A1I7Q442
Ensembl - ENSGALG00000015422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg1ENSDARG00000104314Danio rerio
 NRG1ENSG00000157168Homo sapiens
 Nrg1ENSMUSG00000062991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRG2 / neuregulin 2 / O14511*ENSGALG0000003364132
NRG3 / neuregulin 3 / O35181* / P56975* / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3*ENSGALG0000004281212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018250  Neuregulin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0003161 cardiac conduction system development IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008366 axon ensheathment IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021781 glial cell fate commitment IEA
 biological_processGO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0031643 positive regulation of myelination IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0038129 ERBB3 signaling pathway IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0045213 neurotransmitter receptor metabolic process IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060379 cardiac muscle cell myoblast differentiation IEA
 biological_processGO:0060956 endocardial cell differentiation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005176 ErbB-2 class receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0043125 ErbB-3 class receptor binding IEA
 molecular_functionGO:0045499 chemorepellent activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000010624 MEMO1 / mediator of cell motility 1 / Q91VH6* / Q9Y316* / Protein MEMO1 *  / reaction / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction / complex
 ENSGALG00000000736 MATK / megakaryocyte-associated tyrosine kinase / P42679*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / complex / reaction
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000032819 RNF41 / ring finger protein 41 / Q8BH75* / Q9H4P4* / E3 ubiquitin-protein ligase NRDP1 *  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr