ENSG00000157168


Homo sapiens

Features
Gene ID: ENSG00000157168
  
Biological name :NRG1
  
Synonyms : neuregulin 1 / NRG1 / Q02297
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p12
Gene start: 31639386
Gene end: 32767959
  
Corresponding Affymetrix probe sets: 206237_s_at (Human Genome U133 Plus 2.0 Array)   206343_s_at (Human Genome U133 Plus 2.0 Array)   208230_s_at (Human Genome U133 Plus 2.0 Array)   208231_at (Human Genome U133 Plus 2.0 Array)   208232_x_at (Human Genome U133 Plus 2.0 Array)   208241_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432052
Ensembl peptide - ENSP00000430862
Ensembl peptide - ENSP00000433289
Ensembl peptide - ENSP00000486375
Ensembl peptide - ENSP00000483727
Ensembl peptide - ENSP00000439276
Ensembl peptide - ENSP00000434640
Ensembl peptide - ENSP00000433350
Ensembl peptide - ENSP00000287842
Ensembl peptide - ENSP00000349275
Ensembl peptide - ENSP00000384620
Ensembl peptide - ENSP00000428411
Ensembl peptide - ENSP00000428546
Ensembl peptide - ENSP00000428828
Ensembl peptide - ENSP00000429067
Ensembl peptide - ENSP00000429582
Ensembl peptide - ENSP00000430053
Ensembl peptide - ENSP00000430120
NCBI entrez gene - 3084     See in Manteia.
OMIM - 142445
RefSeq - NM_001159995
RefSeq - NM_001159996
RefSeq - NM_001159999
RefSeq - NM_001160001
RefSeq - NM_001160004
RefSeq - NM_001160005
RefSeq - NM_001160008
RefSeq - NM_001322197
RefSeq - NM_001322201
RefSeq - NM_001322202
RefSeq - NM_001322203
RefSeq - NM_001322205
RefSeq - NM_004495
RefSeq - NM_013956
RefSeq - NM_013957
RefSeq - NM_013958
RefSeq - NM_013959
RefSeq - NM_013960
RefSeq - NM_013962
RefSeq - NM_013964
RefSeq - XM_005273486
RefSeq - XM_011544512
RefSeq - XM_017013365
RefSeq - XM_017013366
RefSeq - XM_017013367
RefSeq - XM_017013368
RefSeq - XM_017013369
RefSeq - XM_017013370
RefSeq - XM_017013371
RefSeq - XM_017013372
RefSeq Peptide - NP_001153467
RefSeq Peptide - NP_001309130
RefSeq Peptide - NP_001309131
RefSeq Peptide - NP_001309134
RefSeq Peptide - NP_004486
RefSeq Peptide - NP_039250
RefSeq Peptide - NP_039251
RefSeq Peptide - NP_039252
RefSeq Peptide - NP_039253
RefSeq Peptide - NP_039254
RefSeq Peptide - NP_039256
RefSeq Peptide - NP_039258
RefSeq Peptide - NP_001153468
RefSeq Peptide - NP_001153471
RefSeq Peptide - NP_001153473
RefSeq Peptide - NP_001153476
RefSeq Peptide - NP_001153477
RefSeq Peptide - NP_001153480
RefSeq Peptide - NP_001309126
swissprot - E7EX30
swissprot - E5RIG8
swissprot - E5RHQ1
swissprot - E5RHP6
swissprot - A0A0D9SF85
swissprot - F6RJN6
swissprot - H0YBA3
swissprot - H0YCP0
swissprot - H0YDC2
swissprot - A0A087X0X9
swissprot - Q02297
Ensembl - ENSG00000157168
  
Related genetic diseases (OMIM): 603013 - {?Schizophrenia, susceptibility to}, 603013
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrg1ENSDARG00000104314Danio rerio
 NRG1ENSGALG00000015422Gallus gallus
 Nrg1ENSMUSG00000062991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRG2 / O14511 / neuregulin 2ENSG0000015845834
NRG3 / P56975 / neuregulin 3ENSG0000018573713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018250  Neuregulin-1
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0003161 cardiac conduction system development IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IDA
 biological_processGO:0007154 cell communication TAS
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008366 axon ensheathment IEA
 biological_processGO:0009790 embryo development IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014032 neural crest cell development TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021781 glial cell fate commitment IEA
 biological_processGO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030879 mammary gland development TAS
 biological_processGO:0031643 positive regulation of myelination IEA
 biological_processGO:0032148 activation of protein kinase B activity IMP
 biological_processGO:0038127 ERBB signaling pathway IDA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0038129 ERBB3 signaling pathway IDA
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043496 regulation of protein homodimerization activity TAS
 biological_processGO:0043497 regulation of protein heterodimerization activity IDA
 biological_processGO:0045213 neurotransmitter receptor metabolic process IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051048 negative regulation of secretion IDA
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0055007 cardiac muscle cell differentiation ISS
 biological_processGO:0060379 cardiac muscle cell myoblast differentiation IDA
 biological_processGO:0060956 endocardial cell differentiation IDA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 biological_processGO:2000145 regulation of cell motility TAS
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2001223 negative regulation of neuron migration IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005176 ErbB-2 class receptor binding IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0008083 growth factor activity NAS
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity NAS
 molecular_functionGO:0030971 receptor tyrosine kinase binding NAS
 molecular_functionGO:0043125 ErbB-3 class receptor binding IDA
 molecular_functionGO:0045499 chemorepellent activity IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction / complex
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / complex / reaction
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000007264 MATK / P42679 / megakaryocyte-associated tyrosine kinase  / reaction / complex
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction
 ENSG00000162959 MEMO1 / Q9Y316 / mediator of cell motility 1  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000131504 DIAPH1 / O60610 / diaphanous related formin 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000181852 RNF41 / Q9H4P4 / ring finger protein 41  / complex / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000151694 ADAM17 / P78536 / ADAM metallopeptidase domain 17  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / complex / reaction






 

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