ENSG00000007264


Homo sapiens

Features
Gene ID: ENSG00000007264
  
Biological name :MATK
  
Synonyms : MATK / megakaryocyte-associated tyrosine kinase / P42679
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3777970
Gene end: 3802129
  
Corresponding Affymetrix probe sets: 206267_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483213
Ensembl peptide - ENSP00000468465
Ensembl peptide - ENSP00000468576
Ensembl peptide - ENSP00000308734
Ensembl peptide - ENSP00000378481
Ensembl peptide - ENSP00000378485
Ensembl peptide - ENSP00000465556
Ensembl peptide - ENSP00000465761
Ensembl peptide - ENSP00000467006
Ensembl peptide - ENSP00000467472
Ensembl peptide - ENSP00000467992
Ensembl peptide - ENSP00000468030
NCBI entrez gene - 4145     See in Manteia.
OMIM - 600038
RefSeq - XM_011528018
RefSeq - NM_002378
RefSeq - NM_139354
RefSeq - NM_139355
RefSeq Peptide - NP_647612
RefSeq Peptide - NP_002369
RefSeq Peptide - NP_647611
swissprot - K7ERY4
swissprot - K7ES68
swissprot - P42679
swissprot - F1T0G6
swissprot - K7EKC4
swissprot - K7EKS5
swissprot - K7EPP2
swissprot - K7ENL8
swissprot - K7EQV3
swissprot - K7EQY5
Ensembl - ENSG00000007264
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 matkENSDARG00000074670Danio rerio
 MATKENSGALG00000000736Gallus gallus
 MatkENSMUSG00000004933Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSK / P41240 / C-terminal Src kinaseENSG0000010365346
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332235
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700734
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251132
FER / P16591 / FER tyrosine kinaseENSG0000015142231
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326330
TXK / P42681 / TXK tyrosine kinaseENSG0000007496629
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560529
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067128
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035026  Tyrosine-protein kinase CSK
 IPR035027  CSK-like, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction / complex
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction / complex






 

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