ENSG00000124882


Homo sapiens

Features
Gene ID: ENSG00000124882
  
Biological name :EREG
  
Synonyms : epiregulin / EREG / O14944
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 74365143
Gene end: 74388751
  
Corresponding Affymetrix probe sets: 1569583_at (Human Genome U133 Plus 2.0 Array)   205767_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244869
NCBI entrez gene - 2069     See in Manteia.
OMIM - 602061
RefSeq - NM_001432
RefSeq Peptide - NP_001423
swissprot - O14944
Ensembl - ENSG00000124882
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EREGENSGALG00000010864Gallus gallus
 EregENSMUSG00000029377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001550 ovarian cumulus expansion IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0007143 female meiotic nuclear division IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009299 mRNA transcription IDA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation TAS
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0042108 positive regulation of cytokine biosynthetic process IDA
 biological_processGO:0042327 positive regulation of phosphorylation ISS
 biological_processGO:0042700 luteinizing hormone signaling pathway IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043616 keratinocyte proliferation IDA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity ISS
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048160 primary follicle stage IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation TAS
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000162959 MEMO1 / Q9Y316 / mediator of cell motility 1  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction
 ENSG00000007264 MATK / P42679 / megakaryocyte-associated tyrosine kinase  / reaction / complex
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction / complex
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction / complex
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction / complex
 ENSG00000131504 DIAPH1 / O60610 / diaphanous related formin 1  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / reaction
 ENSG00000151694 ADAM17 / P78536 / ADAM metallopeptidase domain 17  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction / complex






 

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