ENSGALG00000010864


Gallus gallus

Features
Gene ID: ENSGALG00000010864
  
Biological name :EREG
  
Synonyms : EREG / proepiregulin precursor
  
Possible biological names infered from orthology : epiregulin / O14944 / Proepiregulin Epiregulin / Q61521
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 45042456
Gene end: 45050324
  
Corresponding Affymetrix probe sets: Gga.10155.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017642
NCBI entrez gene - 408036     See in Manteia.
RefSeq - NM_001001203
RefSeq Peptide - NP_001001203
swissprot - F1NJR9
Ensembl - ENSGALG00000010864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EREGENSG00000124882Homo sapiens
 EregENSMUSG00000029377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009299 mRNA transcription IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0042108 positive regulation of cytokine biosynthetic process IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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