ENSG00000169752


Homo sapiens

Features
Gene ID: ENSG00000169752
  
Biological name :NRG4
  
Synonyms : neuregulin 4 / NRG4 / Q8WWG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.2
Gene start: 75935969
Gene end: 76059795
  
Corresponding Affymetrix probe sets: 242426_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457626
Ensembl peptide - ENSP00000457335
Ensembl peptide - ENSP00000457838
Ensembl peptide - ENSP00000378367
Ensembl peptide - ENSP00000431810
Ensembl peptide - ENSP00000432751
Ensembl peptide - ENSP00000436832
Ensembl peptide - ENSP00000454895
Ensembl peptide - ENSP00000455167
Ensembl peptide - ENSP00000455314
Ensembl peptide - ENSP00000456029
Ensembl peptide - ENSP00000456778
NCBI entrez gene - 145957     See in Manteia.
OMIM - 610894
RefSeq - XM_017021948
RefSeq - XM_017021942
RefSeq - XM_017021943
RefSeq - XM_017021944
RefSeq - XM_017021945
RefSeq - XM_017021946
RefSeq - XM_017021947
RefSeq - NM_138573
RefSeq - XM_017021937
RefSeq - XM_017021938
RefSeq - XM_017021939
RefSeq - XM_017021940
RefSeq - XM_017021941
RefSeq Peptide - NP_612640
swissprot - H3BP63
swissprot - E9PJI7
swissprot - Q0P6N6
swissprot - Q7Z663
swissprot - Q8WWG1
Ensembl - ENSG00000169752
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRG4ENSGALG00000002952Gallus gallus
 Nrg4ENSMUSG00000032311Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048513 animal organ development IBA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / reaction
 ENSG00000151694 ADAM17 / P78536 / ADAM metallopeptidase domain 17  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / complex / reaction
 ENSG00000131504 DIAPH1 / O60610 / diaphanous related formin 1  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction / complex
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000007264 MATK / P42679 / megakaryocyte-associated tyrosine kinase  / complex / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction / complex
 ENSG00000162959 MEMO1 / Q9Y316 / mediator of cell motility 1  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction / complex






 

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