ENSG00000127947


Homo sapiens

Features
Gene ID: ENSG00000127947
  
Biological name :PTPN12
  
Synonyms : protein tyrosine phosphatase, non-receptor type 12 / PTPN12 / Q05209
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.23
Gene start: 77537275
Gene end: 77640071
  
Corresponding Affymetrix probe sets: 202006_at (Human Genome U133 Plus 2.0 Array)   216884_at (Human Genome U133 Plus 2.0 Array)   216915_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404050
Ensembl peptide - ENSP00000397991
Ensembl peptide - ENSP00000413449
Ensembl peptide - ENSP00000430726
Ensembl peptide - ENSP00000428735
Ensembl peptide - ENSP00000248594
Ensembl peptide - ENSP00000385079
Ensembl peptide - ENSP00000392429
Ensembl peptide - ENSP00000392526
Ensembl peptide - ENSP00000397364
NCBI entrez gene - 5782     See in Manteia.
OMIM - 600079
RefSeq - XM_017012474
RefSeq - NM_001131008
RefSeq - NM_001131009
RefSeq - NM_002835
RefSeq - XM_005250518
RefSeq - XM_006716073
RefSeq - XM_011516444
RefSeq Peptide - NP_001124481
RefSeq Peptide - NP_001124480
RefSeq Peptide - NP_002826
swissprot - C9JYA4
swissprot - C9JJC1
swissprot - F8WB51
swissprot - H0YB59
swissprot - H0YC15
swissprot - H3BM04
swissprot - Q05209
swissprot - C9J1X8
Ensembl - ENSG00000127947
  
Related genetic diseases (OMIM): 114500 - Colon cancer, somatic, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000042569Gallus gallus
 P35831ENSMUSG00000028771Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22ENSG0000013424237
PTPN18 / Q99952 / protein tyrosine phosphatase, non-receptor type 18ENSG0000007213522
PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type JENSG0000014917714
PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1ENSG0000019639614
PTPRH / Q9HD43 / protein tyrosine phosphatase, receptor type HENSG0000008003114
PTPRB / P23467 / protein tyrosine phosphatase, receptor type BENSG0000012732913
PTPRO / Q16827 / protein tyrosine phosphatase, receptor type OENSG0000015149013
PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2ENSG0000017535413
PTPN9 / P43378 / protein tyrosine phosphatase, non-receptor type 9ENSG0000016941013
PTPRQ / protein tyrosine phosphatase, receptor type QENSG0000013930412
PTPN20 / Q4JDL3 / protein tyrosine phosphatase, non-receptor type 20ENSG0000020417912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012266  Protein-tyrosine phosphatase, non-receptor type-12
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IMP
 biological_processGO:1901185 negative regulation of ERBB signaling pathway TAS
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway TAS
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI


Pathways (from Reactome)
Pathway description
SHC1 events in ERBB2 signaling
EGFR downregulation
Signaling by PDGF
Downregulation of ERBB2 signaling
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction






 

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