ENSG00000105401


Homo sapiens

Features
Gene ID: ENSG00000105401
  
Biological name :CDC37
  
Synonyms : CDC37 / cell division cycle 37 / Q16543
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 10391134
Gene end: 10420121
  
Corresponding Affymetrix probe sets: 209953_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465941
Ensembl peptide - ENSP00000465724
Ensembl peptide - ENSP00000467747
Ensembl peptide - ENSP00000222005
Ensembl peptide - ENSP00000464889
Ensembl peptide - ENSP00000464971
NCBI entrez gene - 11140     See in Manteia.
OMIM - 605065
RefSeq - XM_011527652
RefSeq - NM_007065
RefSeq Peptide - NP_008996
swissprot - K7EKQ2
swissprot - K7EL68
swissprot - K7EQA9
swissprot - A0A024R7B7
swissprot - Q16543
swissprot - K7EJ06
swissprot - K7EIU0
Ensembl - ENSG00000105401
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC37ENSDARG00000099301Danio rerio
 Cdc37ENSMUSG00000019471Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7L3B6 / CDC37L1 / cell division cycle 37 like 1ENSG0000010699333


Protein motifs (from Interpro)
Interpro ID Name
 IPR004918  Cdc37
 IPR013855  Cdc37, N-terminal domain
 IPR013873  Cdc37, C-terminal
 IPR013874  Cdc37, Hsp90 binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0006457 protein folding IBA
 biological_processGO:0006605 protein targeting TAS
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0050821 protein stabilization IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1990565 HSP90-CDC37 chaperone complex IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019887 protein kinase regulator activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0051082 unfolded protein binding TAS
 molecular_functionGO:0051087 chaperone binding IBA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex






 

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