ENSG00000182511


Homo sapiens

Features
Gene ID: ENSG00000182511
  
Biological name :FES
  
Synonyms : FES / FES proto-oncogene, tyrosine kinase / P07332
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 90883695
Gene end: 90895776
  
Corresponding Affymetrix probe sets: 205418_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395425
Ensembl peptide - ENSP00000392696
Ensembl peptide - ENSP00000400868
Ensembl peptide - ENSP00000454146
Ensembl peptide - ENSP00000454089
Ensembl peptide - ENSP00000435811
Ensembl peptide - ENSP00000414629
Ensembl peptide - ENSP00000410477
Ensembl peptide - ENSP00000331504
Ensembl peptide - ENSP00000377837
Ensembl peptide - ENSP00000377839
NCBI entrez gene - 2242     See in Manteia.
OMIM - 190030
RefSeq - XM_017022010
RefSeq - NM_001143783
RefSeq - NM_001143784
RefSeq - NM_001143785
RefSeq - NM_002005
RefSeq - XM_005254880
RefSeq - XM_005254882
RefSeq - XM_017022005
RefSeq - XM_017022006
RefSeq - XM_017022007
RefSeq - XM_017022008
RefSeq - XM_017022009
RefSeq Peptide - NP_001137257
RefSeq Peptide - NP_001996
RefSeq Peptide - NP_001137256
RefSeq Peptide - NP_001137255
swissprot - E7EMJ7
swissprot - C9J3W6
swissprot - H0YNN8
swissprot - H0YNT6
swissprot - P07332
swissprot - A0A024RC92
swissprot - E9PIJ7
swissprot - E9PGC7
swissprot - E7ENM8
Ensembl - ENSG00000182511
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fesENSDARG00000011449Danio rerio
 FESENSGALG00000008340Gallus gallus
 FesENSMUSG00000053158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FER / P16591 / FER tyrosine kinaseENSG0000015142251
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326322
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201022
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560521
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332221
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700721
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067120
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726420
TXK / P42681 / TXK tyrosine kinaseENSG0000007496620
CSK / P41240 / C-terminal Src kinaseENSG0000010365319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035849  Fes/Fps/Fer, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043304 regulation of mast cell degranulation IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0060627 regulation of vesicle-mediated transport TAS
 biological_processGO:2000145 regulation of cell motility IMP
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / reaction / complex
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / complex / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / complex / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex






 

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