ENSMUSG00000029816


Mus musculus

Features
Gene ID: ENSMUSG00000029816
  
Biological name :Gpnmb
  
Synonyms : Gpnmb / Q99P91 / Transmembrane glycoprotein NMB
  
Possible biological names infered from orthology : glycoprotein nmb / Q14956
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.3
Gene start: 49036546
Gene end: 49070929
  
Corresponding Affymetrix probe sets: 10538187 (MoGene1.0st)   1439345_at (Mouse Genome 430 2.0 Array)   1448303_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145376
Ensembl peptide - ENSMUSP00000031840
Ensembl peptide - ENSMUSP00000145090
NCBI entrez gene - 93695     See in Manteia.
MGI - MGI:1934765
RefSeq - NM_053110
RefSeq Peptide - NP_444340
swissprot - A0A0N4SVG5
swissprot - Q8BVA0
swissprot - Q99P91
Ensembl - ENSMUSG00000029816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpnmbENSDARG00000062688Danio rerio
 GPNMBENSGALG00000010949Gallus gallus
 GPNMBENSG00000136235Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pmel / premelanosome protein / P40967*ENSMUSG0000002535930


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR013783  Immunoglobulin-like fold
 IPR022409  PKD/Chitinase domain
 IPR035986  PKD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0034103 regulation of tissue remodeling IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0045545 syndecan binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001059 optic nerve atrophy "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1isa/Tyrp1isa
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ascl2tm1Alj/Ascl2+
Genetic Background: involves: 129 * CD-1

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1b/Tyrp1b
Genetic Background: B6.D2-Tyrp1b GpnmbR150X

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Allelic Composition: GpnmbR150X/GpnmbR150X
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: GpnmbR150X/GpnmbR150X
Genetic Background: B6.D2-GpnmbR150X

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1b/Tyrp1b
Genetic Background: B6.D2-Tyrp1b GpnmbR150X

 MP:0005199 abnormal iris pigment epithelium "anomaly in the epithelial layer of the iris composed of cells containing pigment granules " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1isa/Tyrp1isa
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005208 abnormal iris stroma morphology "structural anomaly of the lamellated connective tissue of the iris" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1isa/Tyrp1isa
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005257 abnormal intraocular pressure "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1b/Tyrp1b
Genetic Background: B6.D2-Tyrp1b GpnmbR150X

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Fkbp5tm1b(KOMP)Wtsi/Fkbp5+
Genetic Background: C57BL/6N-Fkbp5tm1b(KOMP)Wtsi/Ucd

 MP:0006228 iris atrophy "wasting of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: GpnmbR150X/GpnmbR150X
Genetic Background: B6.D2-GpnmbR150X

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1b/Tyrp1b
Genetic Background: B6.D2-Tyrp1b GpnmbR150X

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL

Allelic Composition: GpnmbR150X/GpnmbR150X,Tyrp1isa/Tyrp1isa
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Fkbp5tm1b(KOMP)Wtsi/Fkbp5+
Genetic Background: C57BL/6N-Fkbp5tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000036273 Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*  / complex






 

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