ENSMUSG00000025359


Mus musculus

Features
Gene ID: ENSMUSG00000025359
  
Biological name :Pmel
  
Synonyms : Pmel / premelanosome protein
  
Possible biological names infered from orthology : P40967
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128704195
Gene end: 128720238
  
Corresponding Affymetrix probe sets: 10367379 (MoGene1.0st)   1422523_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051869
Ensembl peptide - ENSMUSP00000151621
Ensembl peptide - ENSMUSP00000151602
NCBI entrez gene - 20431     See in Manteia.
MGI - MGI:98301
RefSeq - NM_021882
RefSeq - XM_006513405
RefSeq Peptide - NP_068682
swissprot - A0A1W2P7H5
swissprot - Q9CZB2
swissprot - A0A1W2P7B8
Ensembl - ENSMUSG00000025359
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pmelaENSDARG00000091298Danio rerio
 pmelbENSDARG00000033760Danio rerio
 PMELENSGALG00000035350Gallus gallus
 PMELENSG00000185664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpnmb / Q99P91 / Transmembrane glycoprotein NMB / Q14956* / glycoprotein nmb*ENSMUSG0000002981627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR013783  Immunoglobulin-like fold
 IPR022409  PKD/Chitinase domain
 IPR035986  PKD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032438 melanosome organization IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008732 reduced hair shaft melanin granule number "the number of pigment polymers in the hair shaft is less than normal" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009933 abnormal tail hair pigmentation "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010192 abnormal retinal melanin granule morphology "any structural anomaly of the pigment particles in the retina" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010193 abnormal choroid melanin granule morphology "any structural anomaly of the pigment particles in the choroid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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