ENSG00000149968


Homo sapiens

Features
Gene ID: ENSG00000149968
  
Biological name :MMP3
  
Synonyms : matrix metallopeptidase 3 / MMP3 / P08254
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.2
Gene start: 102835801
Gene end: 102843803
  
Corresponding Affymetrix probe sets: 205828_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398346
Ensembl peptide - ENSP00000435255
Ensembl peptide - ENSP00000299855
NCBI entrez gene - 4314     See in Manteia.
OMIM - 185250
RefSeq - NM_002422
RefSeq Peptide - NP_002413
swissprot - E9PKX2
swissprot - H7C139
swissprot - P08254
Ensembl - ENSG00000149968
  
Related genetic diseases (OMIM): 614466 - {Coronary heart disease, susceptibility to, 6}, 614466
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026297Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667078
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661153
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767551
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240650
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774550
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811350
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767446
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299640
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596639
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722739
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610338
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851637
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859836
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995335
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010727 negative regulation of hydrogen peroxide metabolic process IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IDA
 biological_processGO:0071732 cellular response to nitric oxide TAS
 biological_processGO:1903209 positive regulation of oxidative stress-induced cell death ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by Gastrin
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164344 KLKB1 / P03952 / kallikrein B1  / reaction
 ENSG00000122194 PLG / P00747 / plasminogen  / reaction
 ENSG00000204983 PRSS1 / P07477 / serine protease 1  / reaction
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction
 ENSG00000116962 NID1 / P14543 / nidogen 1  / reaction
 ENSG00000175899 A2M / P01023 / alpha-2-macroglobulin  / complex / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction
 ENSG00000137745 MMP13 / P45452 / matrix metallopeptidase 13  / reaction
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction
 ENSG00000011465 DCN / P07585 / decorin  / reaction
 ENSG00000168925 CTRB1 / P17538 / chymotrypsinogen B1  / reaction






 

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