ENSG00000008516


Homo sapiens

Features
Gene ID: ENSG00000008516
  
Biological name :MMP25
  
Synonyms : matrix metallopeptidase 25 / MMP25 / Q9NPA2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 3046681
Gene end: 3060726
  
Corresponding Affymetrix probe sets: 207289_at (Human Genome U133 Plus 2.0 Array)   207890_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337816
Ensembl peptide - ENSP00000482854
NCBI entrez gene - 64386     See in Manteia.
OMIM - 608482
RefSeq - XM_017023561
RefSeq - NM_022468
RefSeq - XM_011522602
RefSeq - XM_011522604
RefSeq Peptide - NP_071913
swissprot - O43923
swissprot - Q9NPA2
Ensembl - ENSG00000008516
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp25aENSDARG00000077290Danio rerio
 mmp25bENSDARG00000010556Danio rerio
 Mmp25ENSMUSG00000023903Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859847
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722736
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299636
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610334
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596634
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995333
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996831
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667030
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811330
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774529
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661129
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767428
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767528
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240628
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028733  Matrix metalloproteinase-25
 IPR033739  Peptidase M10A, catalytic domain
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0060022 hard palate development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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