ENSG00000137673


Homo sapiens

Features
Gene ID: ENSG00000137673
  
Biological name :MMP7
  
Synonyms : matrix metallopeptidase 7 / MMP7 / P09237
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.2
Gene start: 102520508
Gene end: 102530753
  
Corresponding Affymetrix probe sets: 204259_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260227
NCBI entrez gene - 4316     See in Manteia.
OMIM - 178990
RefSeq - NM_002423
RefSeq Peptide - NP_002414
swissprot - P09237
Ensembl - ENSG00000137673
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp30ENSDARG00000045887Danio rerio
 MMP7ENSGALG00000017184Gallus gallus
 Mmp7ENSMUSG00000018623Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240648
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667048
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767448
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996848
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661147
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767546
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774546
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811345
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299643
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851643
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722740
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596640
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610338
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995333
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859833


Protein motifs (from Interpro)
Interpro ID Name
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028707  Matrilysin
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / complex / reaction
 ENSG00000136943 CTSV / O60911 / cathepsin V  / reaction
 ENSG00000058085 LAMC2 / Q13753 / laminin subunit gamma 2  / reaction
 ENSG00000188770 OPTC / Q9UBM4 / opticin  / reaction
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / reaction
 ENSG00000053747 LAMA3 / Q16787 / laminin subunit alpha 3  / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction
 ENSG00000011465 DCN / P07585 / decorin  / reaction
 ENSG00000196878 LAMB3 / Q13751 / laminin subunit beta 3  / reaction
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction
 ENSG00000116962 NID1 / P14543 / nidogen 1  / reaction
 ENSG00000204983 PRSS1 / P07477 / serine protease 1  / reaction
 ENSG00000143387 CTSK / P43235 / cathepsin K  / reaction
 ENSG00000149968 MMP3 / P08254 / matrix metallopeptidase 3  / reaction






 

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