ENSG00000166670


Homo sapiens

Features
Gene ID: ENSG00000166670
  
Biological name :MMP10
  
Synonyms : matrix metallopeptidase 10 / MMP10 / P09238
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.2
Gene start: 102770503
Gene end: 102780628
  
Corresponding Affymetrix probe sets: 205680_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000279441
Ensembl peptide - ENSP00000441485
NCBI entrez gene - 4319     See in Manteia.
OMIM - 185260
RefSeq - NM_002425
RefSeq Peptide - NP_002416
swissprot - P09238
swissprot - F5GYX7
Ensembl - ENSG00000166670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026297Gallus gallus
 Mmp10ENSMUSG00000047562Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996878
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661152
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767551
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774550
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811349
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240649
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767446
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299638
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596638
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722737
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610337
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995336
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851636
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859835
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030574 collagen catabolic process IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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