ENSMUSG00000047562


Mus musculus

Features
Gene ID: ENSMUSG00000047562
  
Biological name :Mmp10
  
Synonyms : matrix metallopeptidase 10 / Mmp10 / O55123
  
Possible biological names infered from orthology : P09238
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 7502352
Gene end: 7510240
  
Corresponding Affymetrix probe sets: 10583090 (MoGene1.0st)   1420450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034488
NCBI entrez gene - 17384     See in Manteia.
MGI - MGI:97007
RefSeq - NM_019471
RefSeq Peptide - NP_062344
swissprot - A1L3D0
swissprot - O55123
Ensembl - ENSMUSG00000047562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026297Gallus gallus
 MMP10ENSG00000166670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361373
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032350
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580047
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057847
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308946
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972345
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862045
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162044
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095738
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761238
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822637
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179036
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390335
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090134
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943633
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030574 collagen catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129S7-Ifngtm1Ts

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction






 

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