ENSMUSG00000049723


Mus musculus

Features
Gene ID: ENSMUSG00000049723
  
Biological name :Mmp12
  
Synonyms : Macrophage metalloelastase / Mmp12 / P34960
  
Possible biological names infered from orthology : matrix metallopeptidase 12 / P39900
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 7344381
Gene end: 7369499
  
Corresponding Affymetrix probe sets: 10583056 (MoGene1.0st)   1449153_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005950
Ensembl peptide - ENSMUSP00000114129
Ensembl peptide - ENSMUSP00000116080
Ensembl peptide - ENSMUSP00000120225
Ensembl peptide - ENSMUSP00000065291
NCBI entrez gene - 17381     See in Manteia.
MGI - MGI:97005
RefSeq - XM_017313160
RefSeq - NM_001320076
RefSeq - NM_001320077
RefSeq - NM_008605
RefSeq Peptide - NP_001307006
RefSeq Peptide - NP_032631
RefSeq Peptide - NP_001307005
swissprot - Q3TCW6
swissprot - D3Z705
swissprot - Q8BJC0
swissprot - P34960
swissprot - D6RJI9
Ensembl - ENSMUSG00000049723
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP12ENSG00000262406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361347
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032345
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756245
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057842
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580042
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862041
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308940
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162038
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179035
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095735
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761234
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822633
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943632
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390332
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090131
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028718  Macrophage metalloelastase
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050691 regulation of defense response to virus by host IMP
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IEA
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Mmp12tm1Sds/Mmp12tm1Sds
Genetic Background: involves: 129/Sv * 129T2/SvEms

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: either: (involves: 129S4/SvJae) or (involves: C57BL/6)

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: B6.129X1-Elanetm1Sds

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlg4tm1Grnt/Dlg4tm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction






 

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