ENSMUSG00000028226


Mus musculus

Features
Gene ID: ENSMUSG00000028226
  
Biological name :Mmp16
  
Synonyms : Matrix metalloproteinase-16 / Mmp16 / Q9WTR0
  
Possible biological names infered from orthology : matrix metallopeptidase 16 / P51512
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A3
Gene start: 17852893
Gene end: 18119145
  
Corresponding Affymetrix probe sets: 10503448 (MoGene1.0st)   1422626_at (Mouse Genome 430 2.0 Array)   1437568_at (Mouse Genome 430 2.0 Array)   1440161_at (Mouse Genome 430 2.0 Array)   1443412_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116930
Ensembl peptide - ENSMUSP00000139102
Ensembl peptide - ENSMUSP00000121087
Ensembl peptide - ENSMUSP00000029881
NCBI entrez gene - 17389     See in Manteia.
MGI - MGI:1276107
RefSeq - NM_019724
RefSeq - XM_017320017
RefSeq Peptide - NP_062698
swissprot - B1AVH0
swissprot - Q9WTR0
swissprot - V9GXD8
swissprot - B1AVG8
Ensembl - ENSMUSG00000028226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp16bENSDARG00000058876Danio rerio
 MMP16ENSGALG00000032031Gallus gallus
 MMP16ENSG00000156103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761265
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179055
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095753
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390332
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943631
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580030
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361329
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308929
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756229
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162028
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862028
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057828
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090127
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032327
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972326
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028697  Matrix metalloproteinase-16
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IGI
 biological_processGO:0001958 endochondral ossification IGI
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030574 collagen catabolic process IGI
 biological_processGO:0035988 chondrocyte proliferation IGI
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0060348 bone development IGI
 biological_processGO:0097094 craniofacial suture morphogenesis IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000098 abnormal vomer bone morphology "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000103 nasal bone hypoplasia "reduced cell number in the bone which forms the nasal bridge" [J:53370]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000440 domed skull 
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Rgsc573/Krt25Rgsc573
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Krt25Rgsc573/Krt25Rgsc573
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004420 parietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004455 pterygoid bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004869 frontal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the forehead and roof of the eye orbit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009900 vomer bone hypoplasia "underdevelopment of the vomer bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010870 absent bone trabeculae "absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Krt25Rgsc573/Krt25Rgsc573
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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