ENSG00000156103


Homo sapiens

Features
Gene ID: ENSG00000156103
  
Biological name :MMP16
  
Synonyms : matrix metallopeptidase 16 / MMP16 / P51512
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q21.3
Gene start: 88032009
Gene end: 88328025
  
Corresponding Affymetrix probe sets: 207012_at (Human Genome U133 Plus 2.0 Array)   207013_s_at (Human Genome U133 Plus 2.0 Array)   208166_at (Human Genome U133 Plus 2.0 Array)   208167_s_at (Human Genome U133 Plus 2.0 Array)   223614_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000286614
Ensembl peptide - ENSP00000429147
NCBI entrez gene - 4325     See in Manteia.
OMIM - 602262
RefSeq - NM_005941
RefSeq Peptide - NP_005932
swissprot - E5RJA7
swissprot - P51512
Ensembl - ENSG00000156103
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp16bENSDARG00000058876Danio rerio
 MMP16ENSGALG00000032031Gallus gallus
 Mmp16ENSMUSG00000028226Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596666
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299656
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722752
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859832
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851632
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811330
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996830
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661130
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774529
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667029
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767528
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240628
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767428
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995326
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028697  Matrix metalloproteinase-16
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0019538 protein metabolic process TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0035988 chondrocyte proliferation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0097094 craniofacial suture morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction






 

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