ENSG00000118113


Homo sapiens

Features
Gene ID: ENSG00000118113
  
Biological name :MMP8
  
Synonyms : matrix metallopeptidase 8 / MMP8 / P22894
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.2
Gene start: 102711795
Gene end: 102727050
  
Corresponding Affymetrix probe sets: 207329_at (Human Genome U133 Plus 2.0 Array)   231688_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431431
Ensembl peptide - ENSP00000401004
Ensembl peptide - ENSP00000431938
Ensembl peptide - ENSP00000437173
Ensembl peptide - ENSP00000433812
Ensembl peptide - ENSP00000236826
NCBI entrez gene - 4317     See in Manteia.
OMIM - 120355
RefSeq - XM_017017771
RefSeq - NM_001304441
RefSeq - NM_001304442
RefSeq - NM_002424
RefSeq - XM_011542834
RefSeq - XM_011542835
RefSeq - XM_011542836
RefSeq Peptide - NP_002415
RefSeq Peptide - NP_001291371
RefSeq Peptide - NP_001291370
swissprot - H7C1M3
swissprot - P22894
swissprot - E9PIY7
swissprot - E9PL87
swissprot - E9PJB3
Ensembl - ENSG00000118113
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000019061Gallus gallus
 Mmp8ENSMUSG00000005800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661158
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996851
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667050
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774550
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767549
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240648
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767445
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299640
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596639
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610339
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722737
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851636
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859834
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995333
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028709  Neutrophil collagenase
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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