ENSG00000102996


Homo sapiens

Features
Gene ID: ENSG00000102996
  
Biological name :MMP15
  
Synonyms : matrix metallopeptidase 15 / MMP15 / P51511
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q21
Gene start: 58025566
Gene end: 58046901
  
Corresponding Affymetrix probe sets: 203365_s_at (Human Genome U133 Plus 2.0 Array)   243883_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000219271
Ensembl peptide - ENSP00000457084
NCBI entrez gene - 4324     See in Manteia.
OMIM - 602261
RefSeq - NM_002428
RefSeq Peptide - NP_002419
swissprot - A0A024R6U8
swissprot - H3BT97
swissprot - P51511
Ensembl - ENSG00000102996
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp15aENSDARG00000051962Danio rerio
 mmp15bENSDARG00000013072Danio rerio
 MMP15ENSGALG00000038758Gallus gallus
 Mmp15ENSMUSG00000031790Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722751
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596650
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610350
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859831
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851631
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996829
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661128
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811328
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667027
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240627
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995326
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767426
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767526
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774526
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028729  Matrix metalloproteinase-15
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process TAS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction
 ENSG00000116962 NID1 / P14543 / nidogen 1  / reaction






 

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