ENSG00000262406


Homo sapiens

Features
Gene ID: ENSG00000262406
  
Biological name :MMP12
  
Synonyms : matrix metallopeptidase 12 / MMP12 / P39900
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.2
Gene start: 102862736
Gene end: 102875034
  
Corresponding Affymetrix probe sets: 204580_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458585
NCBI entrez gene - 4321     See in Manteia.
OMIM - 601046
RefSeq - NM_002426
RefSeq Peptide - NP_002417
swissprot - P39900
Ensembl - ENSG00000262406
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Mmp12ENSMUSG00000049723Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996851
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661149
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667049
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767548
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811347
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774546
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767443
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722739
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299639
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596638
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610336
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851633
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859832
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995331
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767327


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028718  Macrophage metalloelastase
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process TAS
 biological_processGO:0035313 wound healing, spreading of epidermal cells IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050691 regulation of defense response to virus by host IEA
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IDA
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0001047 core promoter binding IMP
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IMP
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0005518 collagen binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction
 ENSG00000116962 NID1 / P14543 / nidogen 1  / reaction
 ENSG00000138829 FBN2 / P35556 / fibrillin 2  / reaction






 

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