ENSG00000099953


Homo sapiens

Features
Gene ID: ENSG00000099953
  
Biological name :MMP11
  
Synonyms : matrix metallopeptidase 11 / MMP11 / P24347
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.23
Gene start: 23768226
Gene end: 23784316
  
Corresponding Affymetrix probe sets: 203876_s_at (Human Genome U133 Plus 2.0 Array)   203878_s_at (Human Genome U133 Plus 2.0 Array)   235908_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409860
Ensembl peptide - ENSP00000412107
Ensembl peptide - ENSP00000215743
Ensembl peptide - ENSP00000408070
NCBI entrez gene - 4320     See in Manteia.
OMIM - 185261
RefSeq - NM_005940
RefSeq Peptide - NP_005931
swissprot - E9PED7
swissprot - F8WDI7
swissprot - H7C3I7
swissprot - P24347
Ensembl - ENSG00000099953
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp11aENSDARG00000026325Danio rerio
 mmp11bENSDARG00000016718Danio rerio
 MMP11ENSGALG00000005968Gallus gallus
 Mmp11ENSMUSG00000000901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851638
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596636
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299635
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859835
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667035
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722734
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661134
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996834
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774532
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767432
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610332
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767531
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811331
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240630
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028705  Stromelysin-3
 IPR033739  Peptidase M10A, catalytic domain
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0071711 basement membrane organization IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction






 

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