ENSMUSG00000018623


Mus musculus

Features
Gene ID: ENSMUSG00000018623
  
Biological name :Mmp7
  
Synonyms : matrix metallopeptidase 7 / Mmp7
  
Possible biological names infered from orthology : P09237
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 7692090
Gene end: 7699585
  
Corresponding Affymetrix probe sets: 10583133 (MoGene1.0st)   1449478_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018767
NCBI entrez gene - 17393     See in Manteia.
MGI - MGI:103189
RefSeq - NM_010810
RefSeq - NM_001319986
RefSeq Peptide - NP_001306915
RefSeq Peptide - NP_034940
swissprot - Q3UN27
Ensembl - ENSMUSG00000018623
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp30ENSDARG00000045887Danio rerio
 MMP7ENSGALG00000017184Gallus gallus
 MMP7ENSG00000137673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756248
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361347
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057846
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862046
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580045
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032343
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972343
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308941
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179039
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095739
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390339
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162039
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761238
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822636
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090134
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943633


Protein motifs (from Interpro)
Interpro ID Name
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028707  Matrilysin
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Apctm1Mmt/Apc+,Mmp7tm1Lmm/Mmp7tm1Lmm,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

 MP:0003901 abnormal PQ interval "anomaly in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm
Genetic Background: B6.129-Mmp7tm1Lmm

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028111 Ctsk / P55097 / cathepsin K / P43235*  / reaction
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / reaction
 ENSMUSG00000019929 Dcn / P28654 / Decorin / P07585*  / reaction
 ENSMUSG00000010311 Optc / opticin isoform 4 / Q9UBM4* / opticin*  / reaction
 ENSMUSG00000021477 Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*  / reaction






 

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