ENSMUSG00000029304


Mus musculus

Features
Gene ID: ENSMUSG00000029304
  
Biological name :Spp1
  
Synonyms : P10923 / secreted phosphoprotein 1 / Spp1
  
Possible biological names infered from orthology : P10451
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 104435118
Gene end: 104441050
  
Corresponding Affymetrix probe sets: 10523717 (MoGene1.0st)   1449254_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108367
Ensembl peptide - ENSMUSP00000108368
Ensembl peptide - ENSMUSP00000123163
Ensembl peptide - ENSMUSP00000117338
Ensembl peptide - ENSMUSP00000031243
Ensembl peptide - ENSMUSP00000084043
Ensembl peptide - ENSMUSP00000108366
NCBI entrez gene - 20750     See in Manteia.
MGI - MGI:98389
RefSeq - NM_001204202
RefSeq - NM_001204203
RefSeq - NM_001204233
RefSeq - NM_009263
RefSeq - NM_001204201
RefSeq Peptide - NP_001191130
RefSeq Peptide - NP_001191132
RefSeq Peptide - NP_001191162
RefSeq Peptide - NP_033289
RefSeq Peptide - NP_001191131
swissprot - Q547B5
swissprot - D3Z4N2
swissprot - F8WIP8
swissprot - D3Z116
swissprot - P10923
swissprot - D3Z513
Ensembl - ENSMUSG00000029304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPP1ENSGALG00000010926Gallus gallus
 SPP1ENSG00000118785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002038  Osteopontin
 IPR019841  Osteopontin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IBA
 biological_processGO:0006710 androgen catabolic process ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0030593 neutrophil chemotaxis IGI
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0033280 response to vitamin D ISO
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0045780 positive regulation of bone resorption IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0071394 cellular response to testosterone stimulus ISO
 biological_processGO:0071498 cellular response to fluid shear stress IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000866 positive regulation of estradiol secretion ISO
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005125 cytokine activity NAS
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: B6.129-Ldlrtm1Her Tcra-Jtm1Tgi

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Aprttm1Jat/Aprttm1Jat,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Aprttm1Jat/Aprttm1Jat,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Spp1tm1.1Dhd/Spp1tm1.1Dhd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: BKSW.129S6-Spp1tm1Blh

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * MRL/Mp

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aprttm1Jat/Aprttm1Jat,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.129P2-Nos3tm1Unc

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aprttm1Jat/Aprttm1Jat,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: A/J

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: BALB/cJ

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57BL/6J

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: C57L/J

Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: SWR/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1Ric-r/Spp1+
Genetic Background: SWR/J

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: C3H/HeJ

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: C3H/HeN

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: C3H/St

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: CBA/J

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: DBA/1J

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: DBA/2J

Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: SJL/J

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1tm1.1Dhd/Spp1tm1.1Dhd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Mnt/Ins2tm1Mnt,Tg(Aire-cre)1Mnt/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh,Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Spp1tm1Blh Umodtm1Xrw

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh,Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Spp1tm1Blh Umodtm1Xrw

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004262 abnormal physical strength "altered ability of an organism to exert force on physical objects or of the body to support its load" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004822 decreased susceptibility to experimental autoimmune uveoretinitis "reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh,Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Spp1tm1Blh Umodtm1Xrw

 MP:0004880 lung cysts 
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spp1tm1.1Dhd/Spp1tm1.1Dhd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Y,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmdmdx,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: B6.129-Ldlrtm1Her Tcra-Jtm1Tgi

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: SJL/J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0006116 aortic valve calcification "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: BKSW.129S6-Spp1tm1Blh

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic Background: B6.129-Ldlrtm1Her Tcra-Jtm1Tgi

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: B6.129S7-Spp1tm1Rit

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: B6.129S7-Spp1tm1Rit

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009645 crystalluria "excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: 129S/SvEv-Spp1tm1Blh

Allelic Composition: Spp1tm1Blh/Spp1tm1Blh,Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Spp1tm1Blh Umodtm1Xrw

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1Ric-s/Spp1+
Genetic Background: SJL/J

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh,Umodtm1Xrw/Umodtm1Xrw
Genetic Background: 129S/SvEv-Spp1tm1Blh Umodtm1Xrw

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011165 abnormal tooth root development "aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
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Allelic Composition: Alpltm1Jlm/Alpltm1Jlm
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: B6.129S6-Spp1tm1Blh

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: 129S/SvEv-Spp1tm1Blh

 MP:0011477 abnormal urine nucleoside level "any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides" [MGI:csmith]
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Allelic Composition: Aprttm1Jat/Aprttm1Jat,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
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Allelic Composition: Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018623 Mmp7 / matrix metallopeptidase 7 / P09237*  / reaction
 ENSMUSG00000000555 Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*  / reaction / complex
 ENSMUSG00000039115 Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*  / reaction / complex
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

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