ENSMUSG00000000555


Mus musculus

Features
Gene ID: ENSMUSG00000000555
  
Biological name :Itga5
  
Synonyms : Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / Itga5 / P11688
  
Possible biological names infered from orthology : integrin subunit alpha 5 / P08648
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 103344286
Gene end: 103366763
  
Corresponding Affymetrix probe sets: 10433114 (MoGene1.0st)   1423267_s_at (Mouse Genome 430 2.0 Array)   1423268_at (Mouse Genome 430 2.0 Array)   1458996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023128
Ensembl peptide - ENSMUSP00000148865
NCBI entrez gene - 16402     See in Manteia.
MGI - MGI:96604
RefSeq - NM_001314041
RefSeq - NM_010577
RefSeq Peptide - NP_001300970
RefSeq Peptide - NP_034707
swissprot - P11688
swissprot - A0A1L1SQ20
Ensembl - ENSMUSG00000000555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga5ENSDARG00000006353Danio rerio
 ITGA5ENSG00000161638Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676845
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708745
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466436
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711128
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534828
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911526
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150725
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700924
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036922
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078922
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859621
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021021
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553321
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224321
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228421
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078621
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083020
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007044 cell-substrate junction assembly IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0007159 leukocyte cell-cell adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IMP
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0045765 regulation of angiogenesis IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rettm2(RET)Heno/Rettm2(RET)Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/Sv * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Itga3tm1Jak/Itga3+,Itga5tm1Hyn/Itga5+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Nischedsn/Nischedsn
Genetic Background: C3H.B6-Nischedsn

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nisch+
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rettm2(RET)Heno/Rettm2(RET)Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S/Sv * C57BL/6 * CBA

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nischedsn
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nisch+
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Itga5tm2.1Hyn/Itga5tm2.1Hyn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nischedsn
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
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Allelic Composition: Tbx21tm1Glm/Tbx21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031849 Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*  / reaction / complex
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex






 

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