ENSMUSG00000026768


Mus musculus

Features
Gene ID: ENSMUSG00000026768
  
Biological name :Itga8
  
Synonyms : A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / Itga8
  
Possible biological names infered from orthology : integrin subunit alpha 8 / P53708
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 12106632
Gene end: 12301922
  
Corresponding Affymetrix probe sets: 10480090 (MoGene1.0st)   1427489_at (Mouse Genome 430 2.0 Array)   1454966_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028106
Ensembl peptide - ENSMUSP00000134154
Ensembl peptide - ENSMUSP00000134238
NCBI entrez gene - 241226     See in Manteia.
MGI - MGI:109442
RefSeq - XM_006497475
RefSeq - NM_001001309
RefSeq Peptide - NP_001001309
swissprot - G3UYN5
swissprot - A2ARA8
swissprot - G3UYV5
Ensembl - ENSMUSG00000026768
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga8ENSDARG00000078717Danio rerio
 ITGA8ENSGALG00000008747Gallus gallus
 ITGA8ENSG00000077943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708746
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055544
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466438
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534828
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711128
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700925
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150725
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911524
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228421
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083021
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078921
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553321
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224321
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036920
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021020
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078619
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594719
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0030030 cell projection organization IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Integrin cell surface interactions
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Itga8tm1Lfr/Itga8tm1Lfr,Spry1tm1.1Jdli/Spry1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

Allelic Composition: Itga3tm1Jak/Itga3+,Itga5tm1Hyn/Itga5+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Itga8tm1.1Rdav/Itga8tm1.1Rdav,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0003604 single kidney 
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0004515 abnormal vestibular hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0004516 fused vestibular hair cell stereocilia "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0004517 decreased vestibular hair cell stereocilia number "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010818 adhesive atelectasis "alveolar collapse in the presence of patent airways, especially when surfactant is inactivated or absent, and is seen in newborn respiratory distress syndrome, acute radiation pneumonitis, or viral pneumonia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0010977 fused right lung lobes "complete or partial fusion of the right lung lobes, indicative of defective lobar septation during embryonic lung development" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0011011 impaired lung lobe morphogenesis "failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cys1cpk/Cys1+
Genetic Background: C.B6(Cg)-Cys1cpk

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / complex / reaction






 

1 s.

 
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