| MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
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| MP:0000062 | increased bone density | "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp
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| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000065 | abnormal bone marrow cavities | "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
|
| MP:0000067 | osteopetrosis | "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat
Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000074 | abnormal neurocranium morphology | "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0000116 | abnormal tooth development | "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0000120 | malocclusion | "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0000121 | failure of tooth eruption | "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat
Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
|
| MP:0000133 | abnormal long bone metaphysis morphology | "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
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| MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000454 | abnormal jaw morphology | "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
|
| MP:0000558 | abnormal tibia morphology | "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
|
| MP:0000578 | ulcerated paws | "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0000604 | amyloidosis | "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1
|
| MP:0000681 | abnormal thyroid gland morphology | "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
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| MP:0001179 | thicker alveolar septa | |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001255 | decreased body height | "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
|
| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsdtm1b(EUCOMM)Wtsi/Ctsdtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ctsdtm1b(EUCOMM)Wtsi/Ics
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
|
| MP:0001533 | abnormal skeleton physiology | "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
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| MP:0001541 | abnormal osteoclast function | "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
|
| MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp
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| MP:0002998 | abnormal bone remodeling | "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
|
| MP:0003173 | decreased lysosomal enzyme secretion | "production of glycoprotein hydrolytic enzymes is decreased compared to normal" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0003723 | abnormal long bone morphology | "malformation of any of the several elongated bones of the extremities
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0003795 | abnormal bone structure | |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
|
| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
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| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
|
| MP:0004189 | abnormal alveolar process | "any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
|
| MP:0004696 | abnormal thyroid follicle morphology | "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
|
| MP:0004697 | abnormal thyroid follicular cell | "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
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| MP:0004913 | absent mandibular angle | "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
|
| MP:0004945 | abnormal bone resorption | "anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0004982 | abnormal osteoclast morphology | "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat
Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
|
| MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
|
| MP:0004993 | decreased bone resorption | "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ppargtm1.1(tTA)Jmgr/Pparg+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0005306 | abnormal phalanx morphology | "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0005468 | abnormal thyroid hormone level | "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
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| MP:0005471 | decreased thyroxine level | "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
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| MP:0005478 | decreased circulating thyroxine level | "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
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| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: B6.129S4-Ctsktm1Ypl
Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0006050 | pulmonary fibrosis | "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0006395 | abnormal epiphyseal plate morphology | "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0006398 | increased long bone epiphyseal plate size | "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0008162 | increased diameter of tibia | "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0008395 | abnormal osteoblast differentiation | "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0008396 | abnormal osteoclast differentiation | "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp
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| MP:0009346 | decreased cancellous bone thickness | "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
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| MP:0009347 | increased cancellous bone thickness | "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
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| MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp
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| MP:0010123 | increased bone mineral content | "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp
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| MP:0010868 | increased bone trabecula number | "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
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| MP:0010872 | increased trabecular bone mass | "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010875 | increased bone volume | "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010876 | decreased bone volume | "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010878 | increased trabecular bone volume | "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
Allelic Composition: Slc4a2tm2Ges/Slc4a2tm2Ges,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010879 | decreased trabecular bone volume | "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010924 | abnormal osteoid morphology | "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
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| MP:0010932 | increased trabecular bone connectivity density | "increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"] |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0010964 | increased compact bone volume | |
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Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
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| MP:0010967 | increased compact bone area | "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsktm1Mbs/Ctsktm1Mbs
Genetic Background: B6.129-Ctsktm1Mbs
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| MP:0013630 | increased bone trabecular spacing | "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
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| MP:0013631 | decreased bone trabecular spacing | "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0020039 | increased bone ossification | "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
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| MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj
Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0020080 | increased bone mineralization | "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Ctsktm1.1Rbar/Ctsktm1.1Rbar,X/Tg(Itgam-cre)AJva
Genetic Background: involves: C57BL/6
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0030029 | wide cranial sutures | "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0030279 | thin neurocranium | "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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| MP:0030388 | large fontanelles | "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna] |
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Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl
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