ENSMUSG00000057446


Mus musculus

Features
Gene ID: ENSMUSG00000057446
  
Biological name :Cts8
  
Synonyms : cathepsin 8 / Cts8 / Q9JI81
  
Possible biological names infered from orthology : cathepsin L / CTSL / P07711
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B2
Gene start: 61246745
Gene end: 61255358
  
Corresponding Affymetrix probe sets: 10409924 (MoGene1.0st)   1420680_at (Mouse Genome 430 2.0 Array)   1446266_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021891
NCBI entrez gene - 56094     See in Manteia.
MGI - MGI:1860275
RefSeq - NM_019541
RefSeq Peptide - NP_062414
swissprot - Q9JI81
Ensembl - ENSMUSG00000057446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctslbENSDARG00000039173Danio rerio
 ctslbENSDARG00000074306Danio rerio
 ctsllENSDARG00000011701Danio rerio
 MGC174155ENSDARG00000095072Danio rerio
 si:dkey-239j18.2ENSDARG00000095254Danio rerio
 si:dkey-239j18.3ENSDARG00000089806Danio rerio
 si:dkey-269i1.4ENSDARG00000095744Danio rerio
 si:dkey-269i1.4ENSDARG00000100833Danio rerio
 si:dkey-26g8.4ENSDARG00000087651Danio rerio
 si:dkey-26g8.5ENSDARG00000089750Danio rerio
 zgc:174153ENSDARG00000079376Danio rerio
 zgc:174154ENSDARG00000075527Danio rerio
 zgc:174855ENSDARG00000094559Danio rerio
 CTSVENSGALG00000012610Gallus gallus
 CTSLENSG00000135047Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487164
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487059
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*ENSMUSG0000005567959
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*ENSMUSG0000005529859
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005672858
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144158
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*ENSMUSG0000004224357
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*ENSMUSG0000002143956
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144055
Q80UB0 / 4930486L24Rik / Testin-2 Testin-1 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005034553
Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*ENSMUSG0000002147752
Ctss / O70370 / cathepsin S / P25774*ENSMUSG0000003864244
Ctsk / P55097 / cathepsin K / P43235*ENSMUSG0000002811143
Ctsf / Q9R013 / cathepsin F / Q9UBX1*ENSMUSG0000008328234
Ctsh / P49935 / cathepsin H / P09668*ENSMUSG0000003235933
Ctsw / P56203 / cathepsin W / P56202*ENSMUSG0000002491031
CT030254.2 / CTSL* / P07711* / cathepsin L*ENSMUSG0000011490422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0006508 proteolysis ISA
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005768 endosome IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity ISA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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