ENSGALG00000028147


Gallus gallus

Features
Gene ID: ENSGALG00000028147
  
Biological name :CTSK
  
Synonyms : cathepsin K / CTSK
  
Possible biological names infered from orthology : P43235 / P55097
  
Species: Gallus gallus
  
Chr. number: 25
Strand: -1
Band:
Gene start: 2586099
Gene end: 2589028
  
Corresponding Affymetrix probe sets: Gga.483.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046303
Ensembl peptide - ENSGALP00000043433
NCBI entrez gene - 395818     See in Manteia.
RefSeq - NM_204971
RefSeq Peptide - NP_990302
swissprot - R4GMG8
swissprot - A0A1D5P0X4
Ensembl - ENSGALG00000028147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctskENSDARG00000040251Danio rerio
 CTSKENSG00000143387Homo sapiens
 CtskENSMUSG00000028111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSS / cathepsin S precursor / O70370* / P25774* / cathepsin S*ENSGALG0000000077547
CTSV / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81* / BC051665* / CT030254...ENSGALG0000001261047
ENSGALG0000000425242
ENSGALG0000001340938
CTSH / cathepsin H / P09668* / P49935*ENSGALG0000003355737
ENSGALG0000002983334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR015644  Peptidase C1A, cathepsin K
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043394 proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017183 MMP13 / collagenase 3 precursor / P45452* / P33435* / Collagenase 3 * / matrix metallopeptidase 13*  / reaction






 

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