ENSGALG00000017183


Gallus gallus

Features
Gene ID: ENSGALG00000017183
  
Biological name :MMP13
  
Synonyms : collagenase 3 precursor / MMP13
  
Possible biological names infered from orthology : Collagenase 3 / matrix metallopeptidase 13 / P33435 / P45452
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 182444413
Gene end: 182451714
  
Corresponding Affymetrix probe sets: Gga.3468.1.S1_at (Chicken Array)   Gga.398.1.S1_at (Chicken Array)   GgaAffx.11018.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027710
NCBI entrez gene - 395683     See in Manteia.
RefSeq - NM_001293090
RefSeq Peptide - NP_001280019
swissprot - F1NZ56
Ensembl - ENSGALG00000017183
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp13bENSDARG00000100794Danio rerio
 MMP13ENSG00000137745Homo sapiens
 Mmp13ENSMUSG00000050578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP1* / MMP8* / Mmp1b* / Mmp1a* / P22894* / P03956* / O70138* / Neutrophil collagenase * / matrix metallopeptidase 1* / matrix metallopeptidase 8* / interstitial collagenase A preproprotein *ENSGALG0000001906149
MMP10ENSGALG0000001906349
MMP27 / matrix metalloproteinase-27 precursor / Q9H306* / matrix metallopeptidase 27*ENSGALG0000001906048
MMP3* / MMP10* / O55123* / P08254* / P09238* / matrix metallopeptidase 3* / matrix metallopeptidase 10*ENSGALG0000002629741
MMP15 / matrix metallopeptidase 15 / O54732* / P51511* / Matrix metalloproteinase-15 *ENSGALG0000003875837
MMP16 / matrix metallopeptidase 16 / P51512* / Q9WTR0* / Matrix metalloproteinase-16 *ENSGALG0000003203137
MMP24 / matrix metallopeptidase 24 / Q9R0S2* / Q9Y5R2* / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24*ENSGALG0000004109337
MMP11 / matrix metallopeptidase 11 / P24347* / Q02853* / Stromelysin-3 *ENSGALG0000000596829
MMP7 / matrilysin precursor / P09237* / matrix metallopeptidase 7*ENSGALG0000001718428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028711  Collagenase 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0003417 growth plate cartilage development IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0044267 cellular protein metabolic process IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060349 bone morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004293 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction
 ENSGALG00000003554 OPTC / opticin precursor / Q9UBM4* / opticin* / opticin isoform 4 *  / reaction
 ENSGALG00000012610 CTSV / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81* / BC051665* / CT030254...  / reaction
 ENSGALG00000028147 CTSK / cathepsin K / P43235* / P55097*  / reaction
 ENSGALG00000028886 LPA* / PLG* / P00747* / P08519* / P20918* / plasminogen* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction






 

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