MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0000619 | salivary gland epithelial hyperplasia | "increased cell number in the epithelium of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: MybM303V/MybM303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
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MP:0000708 | thymus hyperplasia | "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0000709 | enlarged thymus | "increased size of thymus" [J:50053] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0001199 | thin skin | "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0001244 | thin dermal layer | "reduced thickness of the dermis" [J:65030] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001800 | abnormal humoral immune response | "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Dcntm1Ioz/Dcn+ Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: MybM303V/MybM303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1Ruiz/Jup+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002294 | short gestation period | "decrease in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0002411 | decreased susceptibility to bacterial infection | "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Xab2tm2Tnka/Xab2tm2Tnka Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Dcntm1Ioz/Dcn+ Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz
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MP:0002704 | tubular nephritis | "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0003089 | reduced skin tensile strength | "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0003667 | hemangiosarcoma | "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511] |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz,Trp53tm1Brd/Trp53tm1Brd Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6
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MP:0003668 | abnormal periodontal ligament morphology | "any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0003669 | periodontal ligament hypercellularity | "increased cell density of the periodontal ligament" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0004126 | thin hypodermis | "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0004153 | increased renal tubule apoptosis | "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0005421 | loose skin | "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0005503 | abnormal tendon morphology | "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0008151 | increased diameter of long bones | "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0008438 | abnormal cutaneous collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0009640 | abnormal renal tubule epithelium morphology | "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0010792 | abnormal stomach mucosa morphology | "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: MybM303V/MybM303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
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MP:0010873 | decreased trabecular bone mass | "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0010962 | decreased compact bone mass | |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0011501 | increased glomerular capsule space | "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0011642 | abnormal bone collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Y,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0012008 | delayed parturition | "the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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MP:0012009 | early parturition | "the process of labor and delivery in female animals occurs earlier in gestation than expected" [MGI:csmith] |
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Allelic Composition: Bgntm1Mfy/Bgntm1Mfy,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Bgntm1Mfy/Bgn+,Dcntm1Ioz/Dcntm1Ioz Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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