Manteia - Molecule gene

ENSMUSG00000041559

Mus musculus

Features

Gene ID:	ENSMUSG00000041559

Biological name :	Fmod

Synonyms :	Fibromodulin / Fmod / P50608

Possible biological names infered from orthology :	Q06828

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	E4
Gene start:	134037254
Gene end:	134048277

Corresponding Affymetrix probe sets:	10349947 (MoGene1.0st) 1415939_at (Mouse Genome 430 2.0 Array) 1437324_x_at (Mouse Genome 430 2.0 Array) 1437685_x_at (Mouse Genome 430 2.0 Array) 1437718_x_at (Mouse Genome 430 2.0 Array) 1438966_x_at (Mouse Genome 430 2.0 Array) 1456084_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124896 Ensembl peptide - ENSMUSP00000035489 NCBI entrez gene - 14264 See in Manteia. MGI - MGI:1328364 RefSeq - NM_021355 RefSeq Peptide - NP_067330 swissprot - E0CX60 swissprot - P50608 swissprot - Q543D2 Ensembl - ENSMUSG00000041559

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fmoda	ENSDARG00000044895	Danio rerio
fmodb	ENSDARG00000010294	Danio rerio
FMOD	ENSGALG00000034067	Gallus gallus
FMOD	ENSG00000122176	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lum / P51885 / Lumican / P51884*	ENSMUSG00000036446	41
Prelp / Q9JK53 / proline arginine-rich end leucine-rich repeat / P51888* / proline and arginine rich end leucine rich repeat protein*	ENSMUSG00000041577	38
Kera / O35367 / Keratocan / O60938*	ENSMUSG00000019932	35
Omd / O35103 / Osteomodulin / Q99983*	ENSMUSG00000048368	35
Podnl1 / Q6P3Y9 / Podocan-like protein 1 / Q6PEZ8* / podocan like 1*	ENSMUSG00000012889	27
Podn / Q7TQ62 / podocan / Q7Z5L7*	ENSMUSG00000028600	26
Ecm2 / Q5FW85 / Extracellular matrix protein 2 / O94769*	ENSMUSG00000043631	25
Bgn / P28653 / biglycan / P21810*	ENSMUSG00000031375	24
Dcn / P28654 / Decorin / P07585*	ENSMUSG00000019929	24
Aspn / Q99MQ4 / Asporin / Q9BXN1*	ENSMUSG00000021388	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000372	Leucine-rich repeat N-terminal domain
IPR001611	Leucine-rich repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR027215	Fibromodulin
IPR032675	Leucine-rich repeat domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0030199	collagen fibril organization	IMP
cellular_component	GO:0005576	extracellular region	ISO
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

Keratan sulfate biosynthesis

Keratan sulfate degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ppib^{Gt(RST139)Byg}/Ppib^{Gt(RST139)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified
MP:0002697	abnormal eye size	"anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002698	abnormal sclera morphology	"structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0003089	reduced skin tensile strength	"reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0003098	reduced tendon stiffness	"decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0003099	retinal detachment	"detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0003101	high myopia	"an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0003102	sclera thinning	"reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0003560	osteoarthritis	"a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0005353	abnormal patella morphology	"anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0005421	loose skin	"condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0005503	abnormal tendon morphology	"structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fmod^tm1Aol/Fmod⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppib^{Gt(RST139)Byg}/Ppib^{Gt(RST139)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006433	abnormal articular cartilage morphology	"any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: a^jl85/a Genetic Background: Not Specified Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Bgn^tm1Mfy/Bgn^tm1Mfy,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0009275	bruising	"an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fmod^tm1Aol/Fmod^tm1Aol,Lum^tm1Chak/Lum^tm1Chak Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0011643	abnormal tendon collagen fibril morphology	"any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0013304	osteophytes	"bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Bgn^tm1Mfy/Bgn^tm1Mfy,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0014101	decreased chondrocyte proliferation	"decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Bgn^tm1Mfy/Bgn^tm1Mfy,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0030332	accelerated temporomandibular joint osteoarthritis	"earlier onset or more rapid progression of a degenerative condition of the temporomandibular joint that results from breakdown of joint cartilage and underlying bone; erosive lesions and joint space narrowing usually indicate acute or early changes, whereas sclerosis, flattening, subchondral cysts, and osteophytes may indicate late changes" [http://www.sciencedirect.com/science/article/pii/S2319417016301536, MGI:anna]	Show Allelic Composition: Bgn^tm1Mfy/Y,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ Allelic Composition: Bgn^tm1Mfy/Bgn^tm1Mfy,Fmod^tm1Aol/Fmod^tm1Aol Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr