ENSG00000122176


Homo sapiens

Features
Gene ID: ENSG00000122176
  
Biological name :FMOD
  
Synonyms : fibromodulin / FMOD / Q06828
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 203340628
Gene end: 203351489
  
Corresponding Affymetrix probe sets: 202709_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000347041
NCBI entrez gene - 2331     See in Manteia.
OMIM - 600245
RefSeq - NM_002023
RefSeq Peptide - NP_002014
swissprot - A0A024R971
swissprot - Q06828
Ensembl - ENSG00000122176
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fmodaENSDARG00000044895Danio rerio
 fmodbENSDARG00000010294Danio rerio
 FMODENSGALG00000034067Gallus gallus
 FmodENSMUSG00000041559Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LUM / P51884 / lumicanENSG0000013932940
PRELP / P51888 / proline and arginine rich end leucine rich repeat proteinENSG0000018878339
KERA / O60938 / keratocanENSG0000013933035
OMD / Q99983 / osteomodulinENSG0000012708333
PODNL1 / Q6PEZ8 / podocan like 1ENSG0000013200026
PODN / Q7Z5L7 / podocanENSG0000017434825
ECM2 / O94769 / extracellular matrix protein 2ENSG0000010682325
DCN / P07585 / decorinENSG0000001146524
BGN / P21810 / biglycanENSG0000018249224
ASPN / Q9BXN1 / asporinENSG0000010681924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027215  Fibromodulin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007181 transforming growth factor beta receptor complex assembly TAS
 biological_processGO:0018146 keratan sulfate biosynthetic process TAS
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0042340 keratan sulfate catabolic process TAS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Keratan sulfate degradation
ECM proteoglycans
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000119699 TGFB3 / P10600 / transforming growth factor beta 3  / reaction / complex
 ENSG00000092969 TGFB2 / P61812 / transforming growth factor beta 2  / reaction / complex






 

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