ENSG00000106819


Homo sapiens

Features
Gene ID: ENSG00000106819
  
Biological name :ASPN
  
Synonyms : ASPN / asporin / Q9BXN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q22.31
Gene start: 92456205
Gene end: 92482506
  
Corresponding Affymetrix probe sets: 219087_at (Human Genome U133 Plus 2.0 Array)   224396_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364693
Ensembl peptide - ENSP00000364694
NCBI entrez gene - 54829     See in Manteia.
OMIM - 608135
RefSeq - NM_017680
RefSeq - NM_001193335
RefSeq Peptide - NP_001180264
RefSeq Peptide - NP_060150
swissprot - Q5TBF2
swissprot - Q9BXN1
Ensembl - ENSG00000106819
  
Related genetic diseases (OMIM): 603932 - {Lumbar disc degeneration}, 603932
  607850 - {Osteoarthritis susceptibility 3}, 607850
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aspnENSDARG00000002192Danio rerio
 ASPNENSGALG00000004722Gallus gallus
 AspnENSMUSG00000021388Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BGN / P21810 / biglycanENSG0000018249252
DCN / P07585 / decorinENSG0000001146549
LUM / P51884 / lumicanENSG0000013932928
PRELP / P51888 / proline and arginine rich end leucine rich repeat proteinENSG0000018878326
ECM2 / O94769 / extracellular matrix protein 2ENSG0000010682326
PODN / Q7Z5L7 / podocanENSG0000017434824
KERA / O60938 / keratocanENSG0000013933024
OMD / Q99983 / osteomodulinENSG0000012708324
FMOD / Q06828 / fibromodulinENSG0000012217624
PODNL1 / Q6PEZ8 / podocan like 1ENSG0000013200023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR016352  Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
 IPR028548  Asporin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030282 bone mineralization IDA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0070171 negative regulation of tooth mineralization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding IEA


Pathways (from Reactome)
Pathway description
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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