ENSG00000139329


Homo sapiens

Features
Gene ID: ENSG00000139329
  
Biological name :LUM
  
Synonyms : LUM / lumican / P51884
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.33
Gene start: 91102629
Gene end: 91111831
  
Corresponding Affymetrix probe sets: 201744_s_at (Human Genome U133 Plus 2.0 Array)   229554_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000266718
NCBI entrez gene - 4060     See in Manteia.
OMIM - 600616
RefSeq - NM_002345
RefSeq Peptide - NP_002336
swissprot - P51884
Ensembl - ENSG00000139329
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lumENSDARG00000045580Danio rerio
 LUMENSGALG00000011271Gallus gallus
 LumENSMUSG00000036446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FMOD / Q06828 / fibromodulinENSG0000012217645
PRELP / P51888 / proline and arginine rich end leucine rich repeat proteinENSG0000018878339
OMD / Q99983 / osteomodulinENSG0000012708339
KERA / O60938 / keratocanENSG0000013933036
ASPN / Q9BXN1 / asporinENSG0000010681931
ECM2 / O94769 / extracellular matrix protein 2ENSG0000010682330
BGN / P21810 / biglycanENSG0000018249230
DCN / P07585 / decorinENSG0000001146530
PODN / Q7Z5L7 / podocanENSG0000017434827
PODNL1 / Q6PEZ8 / podocan like 1ENSG0000013200025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027219  Lumican
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0018146 keratan sulfate biosynthetic process TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030199 collagen fibril organization NAS
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production IEA
 biological_processGO:0042340 keratan sulfate catabolic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0070848 response to growth factor IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005583 fibrillar collagen trimer IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Keratan sulfate degradation
Integrin cell surface interactions
ECM proteoglycans
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000164171 ITGA2 / P17301 / integrin subunit alpha 2  / reaction / complex






 

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