ENSDARG00000045580


Danio rerio

Features
Gene ID: ENSDARG00000045580
  
Biological name :lum
  
Synonyms : lum / lumican
  
Possible biological names infered from orthology : P51884 / P51885
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 16349042
Gene end: 16354292
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000119600
Ensembl peptide - ENSDARP00000146992
NCBI entrez gene - 415149     See in Manteia.
swissprot - F1R6G3
swissprot - Q6IQQ7
ZFIN ID - ZDB-GENE-040625-24
Ensembl - ENSDARG00000045580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LUMENSGALG00000011271Gallus gallus
 LUMENSG00000139329Homo sapiens
 LumENSMUSG00000036446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fmoda / fibromodulin a / FMOD* / P50608* / Q06828* / fibromodulin*ENSDARG0000004489540
fmodb / fibromodulin b / FMOD* / P50608* / Q06828* / fibromodulin*ENSDARG0000001029440
zgc:113307ENSDARG0000004489433
prelp / proline/arginine-rich end leucine-rich repeat protein / Q9JK53* / P51888* / proline arginine-rich end leucine-rich repeat* / proline and arginine rich end leucine rich repeat protein*ENSDARG0000007059733
kera / Q5RI43 / keratocan / O35367* / O60938*ENSDARG0000005693832
omd / osteomodulin / O35103* / Q99983*ENSDARG0000009360031
dcn / decorin / P07585* / P28654*ENSDARG0000001206627
bgnb / biglycan b / BGN* / P21810* / P28653* / biglycan*ENSDARG0000000294527
bgna / biglycan a / BGN* / P21810* / P28653* / biglycan*ENSDARG0000001788427
aspn / asporin (LRR class 1) / Q99MQ4* / Q9BXN1* / asporin*ENSDARG0000000219226
ecm2 / extracellular matrix protein 2, female organ and adipocyte specific / O94769* / Q5FW85* / extracellular matrix protein 2*ENSDARG0000007154926
si:dkey-6n6.1ENSDARG0000006248725
podn / podocan / Q7TQ62* / Q7Z5L7*ENSDARG0000001902524
si:dkey-32e6.6ENSDARG0000007085723
wu:fc23c09ENSDARG0000008800223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027219  Lumican
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005518 collagen binding IBA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
Keratan sulfate degradation
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye distended , abnormal
Show

 ZFA:0001094 whole organism whole organism hypoplastic , abnormal
Show

 ZFA:0001685 corneal stroma corneal stroma supramolecular fiber increased diameter , abnormal
Show

 ZFA:0005563 sclera sclera anterior region decreased thickness , abnormal
sclera posterior region decreased thickness , abnormal
sclera fibroblast decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction
 ENSDARG00000062974 itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*  / complex / reaction






 

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